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Narcolepsy is a chronic neurological disorder that impairs the ability to regulate sleep–wake cycles, and specifically impacts REM (rapid eye movement) sleep. [1] The pentad symptoms of narcolepsy include excessive daytime sleepiness (EDS), sleep-related hallucinations, sleep paralysis, disturbed nocturnal sleep (DNS), and cataplexy. [1]
Causes Narcolepsy , idiopathic hypersomnia , circadian rhythm sleep disorder , sleep apnea , others Excessive daytime sleepiness ( EDS ) is characterized by persistent sleepiness and often a general lack of energy, even during the day after apparently adequate or even prolonged nighttime sleep.
This condition was first discovered in 1995 by Melberg et al. when they described 5 members of a 4-generation Swedish family where cerebellar ataxia and sensorineural deafness presented as an autosomal dominant trait, 4 of them had narcolepsy and 2 had diabetes mellitus. The oldest members had psychiatric symptoms, neurological anomalies, and ...
Orexin (/ ɒ ˈ r ɛ k s ɪ n /), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. [5] It exists in the forms of orexin-A and orexin-B.The most common form of narcolepsy, type 1, in which the individual experiences brief losses of muscle tone ("drop attacks" or cataplexy), is caused by a lack of orexin in the brain due to destruction of the cells ...
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Narcolepsy with cataplexy 347.01 G47.411 Narcolepsy without cataplexy 347.00 G47.419 Narcolepsy due to medical condition 347.10 G47.421 Narcolepsy, unspecified 347.00 G47.43 Recurrent hypersomnia 780.54 G47.13 - Kleine-Levin Syndrome: 327.13 G47.13 - Menstrual-related hypersomnia 327.13 G47.13 Idiopathic hypersomnia with long sleep time 327.11 ...
Axsome (AXSM) accelerates the development plan for AXS-12 to treat narcolepsy after a Breakthrough Therapy meeting with the FDA authorities. Stock dips.
Sodium oxybate, sold under the brand name Xyrem among others, is a medication used to treat symptoms of narcolepsy: sudden muscle weakness and excessive daytime sleepiness. [3] [8] [9] It is used sometimes in France and Italy as an anesthetic given intravenously.