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The tumor necrosis factor (TNF) superfamily is a protein superfamily of type II transmembrane proteins containing TNF homology domain and forming trimers. Members of this superfamily can be released from the cell membrane by extracellular proteolytic cleavage and function as a cytokine .
The tumor necrosis factor receptor superfamily (TNFRSF) is a protein superfamily of cytokine receptors characterized by the ability to bind tumor necrosis factors (TNFs) via an extracellular cysteine-rich domain. [2] [3] With the exception of nerve growth factor (NGF), all TNFs are homologous to the archetypal TNF-alpha. [4]
It is a member of the tumor necrosis factor superfamily, a family of transmembrane proteins that are cytokines, chemical messengers of the immune system. [7] Excessive production of TNF plays a critical role in several inflammatory diseases, and TNF-blocking drugs are often employed to treat these diseases.
21942 Ensembl ENSG00000049249 ENSMUSG00000028965 UniProt Q07011 P20334 RefSeq (mRNA) NM_001561 NM_001077508 NM_001077509 NM_011612 RefSeq (protein) NP_001552 NP_001070976 NP_001070977 NP_035742 Location (UCSC) Chr 1: 7.92 – 7.94 Mb Chr 4: 151 – 151.03 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse CD137, a member of the tumor necrosis factor (TNF) receptor family, is a type 1 ...
The protein encoded by this gene is a member of the tumor necrosis factor receptor superfamily, which also contains TNFRSF1B. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation.
Over the past several years, former President Donald Trump has benefited significantly from cryptocurrency. He has received millions in cryptocurrency from NFT projects and memecoins, even selling ...
Fred Trump Jr. (b. 1938, d. 1981), the eldest Trump son had been Fred Sr.'s first choice to take over the family business, but ultimately proved a poor fit for that dream. He instead became a ...
21930 Ensembl ENSG00000123610 ENSMUSG00000053475 UniProt P98066 O08859 RefSeq (mRNA) NM_007115 NM_009398 RefSeq (protein) NP_009046 NP_033424 Location (UCSC) Chr 2: 151.36 – 151.38 Mb Chr 2: 51.93 – 51.95 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tumor necrosis factor-inducible gene 6 protein also known as TNF-stimulated gene 6 protein or TSG-6 is a protein that in humans ...