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Mastocytosis, a type of mast cell disease, is a rare disorder affecting both children and adults caused by the accumulation of functionally defective mast cells (also called mastocytes) and CD34+ mast cell precursors. [1]
The diagnosis of mastocytosis is not ruled out in the absence of a positive Darier sign because it is evoked in only around 50% and 90% of patients with solitary mastocytoma and other kinds of cutaneous mastocytosis, respectively. [10] [11] Certain lesions may erupt in painful blisters. [4] [12]
Urticaria pigmentosa (also known as generalized eruption of cutaneous mastocytosis (childhood type) [1]: 616 ) is the most common form of cutaneous mastocytosis. It is a rare disease caused by excessive numbers of mast cells in the skin that produce hives or lesions on the skin when irritated.
Symptoms include abdominal pain, bone pain, and peptic ulcer which are more prevalent than in other subtypes of acute myeloid leukemia. These former symptoms are due to release of a substance called histamine from neoplastic mast cells. [5] Enlargement of the liver and spleen, or hepatosplenomegaly is characteristic. [6]
An estimated 13,000 people have died from flu this season so far, including 57 children. The death toll could reach up to 65,000 by the end of the season, per preliminary estimates from the CDC .
Mast cell activation syndrome (MCAS) is a term referring to one of two types of mast cell activation disorder (MCAD); the other type is idiopathic MCAD. [1] MCAS is an immunological condition in which mast cells, a type of white blood cell, inappropriately and excessively release chemical mediators, such as histamine, resulting in a range of chronic symptoms, sometimes including anaphylaxis or ...
Several years ago, Jill Zinsmeyer was visiting Texas when fire ants bit her and she lost consciousness for 45 minutes.
Recorded deaths totaled at least 216, including 93 newborns under a month old and nine children age 14 and under, according to South Africa’s Department of Health. Others affected were, like ...