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Glutathione peroxidase (GPx) (EC 1.11.1.9) is the general name of an enzyme family with peroxidase activity whose main biological role is to protect the organism from oxidative damage. [2] The biochemical function of glutathione peroxidase is to reduce lipid hydroperoxides to their corresponding alcohols and to reduce free hydrogen peroxide to ...
The antioxidant enzyme glutathione peroxidase 4 (GPX4) belongs to the family of glutathione peroxidases, which consists of 8 known mammalian isoenzymes (GPX1–8).GPX4 catalyzes the reduction of hydrogen peroxide, organic hydroperoxides, and lipid peroxides at the expense of reduced glutathione and functions in the protection of cells against oxidative stress.
The assay is a solid-phase type of enzyme immunoassay (EIA) to detect the presence of a ligand (commonly a protein) in a liquid sample using antibodies directed against the ligand to be measured. ELISA has been used as a diagnostic tool in medicine, plant pathology , and biotechnology , as well as a quality control check in various industries.
Glutathione peroxidase 3 (GPx-3), also known as plasma glutathione peroxidase (GPx-P) or extracellular glutathione peroxidase is an enzyme that in humans is encoded by the GPX3 gene. [5] [6] [7] GPx-3 belongs to the glutathione peroxidase family, which functions in the detoxification of
This gene encodes a member of the glutathione peroxidase family, consisting of eight known glutathione peroxidases (GPx1-8) in humans. Mammalian Gpx1 (this gene), Gpx2, Gpx3, and Gpx4 have been shown to be selenium-containing enzymes, whereas Gpx6 is a selenoprotein in humans with cysteine-containing homologues in rodents.
The assay would also allow for the immediate detection of any amount of LOOHs. With the sensing of LOOHs, the FOX reagent only senses the first products of fatty acid oxidation, and is quite useful prior to the processing of fruits and vegetables. [ 1 ]
Glutathione peroxidase 2 is an enzyme that in humans is encoded by the GPX2 gene. [5] [6] [7]This gene is a member of the glutathione peroxidase family encoding a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract.
69590 Ensembl ENSG00000164294 ENSMUSG00000021760 UniProt Q8TED1 Q9D7B7 RefSeq (mRNA) NM_001008397 NM_001306197 NM_001306198 NM_001306201 NM_027127 RefSeq (protein) NP_001008398 NP_001293126 NP_001293127 NP_001293130 NP_081403 Location (UCSC) Chr 5: 55.16 – 55.17 Mb Chr 13: 113.18 – 113.18 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Glutathione peroxidase 8 (GPx-8) is an ...