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Naltrexone/bupropion, sold under the brand name Contrave among others, is a fixed-dose combination medication for the management of chronic obesity in adults in combination with a reduced-calorie diet and increased physical activity. [4] [6] It contains naltrexone, an opioid antagonist, and bupropion, an aminoketone atypical antidepressant. [4]
Bupropion, when used for treating long-term weight gain over six to twelve months, results in an average weight loss of 2.7 kilograms (6.0 lb) over placebo. [74] This is not much different from the weight loss produced by several other weight-loss medications such as sibutramine or orlistat . [ 74 ]
Here’s what to keep in mind about type 2 diabetes medications used to support weight loss and weight loss injections: Weight loss injections are safe and effective when used as prescribed .
For example, a study published in the Journal of Clinical Medicine in 2016 found that bupropion users lost an average of 7.1 pounds over the course of two years when compared to depressed people ...
In the United States, semaglutide (Wegovy) is approved by the FDA for chronic weight management. [50] The FDA guidelines say that a therapy may be approved if it results in weight loss that is statistically significant greater than placebo and generally at least five percent of body weight over six months that comes predominantly from fat mass.
Contrave: This medication combines bupropion (an antidepressant) and naltrexone (a drug to treat alcohol and opioid dependence) to help control appetite and cravings while increasing metabolism.
Vyvanse (lisdexamfetamine) – a pro-drug stimulant used to treat attention deficit hyperactivity disorder and binge eating disorder; Vyvanse is converted into Dexedrine in vivo; Viibryd – an antidepressant of the serotonin modulator and stimulators class; Vivactil (protriptyline) an antidepressant also used in the treatment of nerve pain
Bupropion had an associated 15% reduced risk of gaining 5% of baseline weight or more. At the 1-year and 2-year marks compared to sertraline, bupropion’s estimations for weight gain were still ...
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