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Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
From chemical level (molecular scale), biological systems show extreme stereospecificity in synthesis, uptake, sensing, metabolic processing. A living system usually deals with two enantiomers of the same compound in drastically different ways. In biology, homochirality is a common property of amino acids and carbohydrates.
This glossary of biology terms is a list of definitions of fundamental terms and concepts used in biology, the study of life and of living organisms.It is intended as introductory material for novices; for more specific and technical definitions from sub-disciplines and related fields, see Glossary of cell biology, Glossary of genetics, Glossary of evolutionary biology, Glossary of ecology ...
Biochemistry, or biological chemistry, is the study of chemical processes within and relating to living organisms. [1] A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, and metabolism. Over the last decades of the 20th century, biochemistry has become successful at ...
The pygmy mammoth is an example of insular dwarfism, a case of Foster's rule, its unusually small body size an adaptation to the limited resources of its island home.. A biological rule or biological law is a generalized law, principle, or rule of thumb formulated to describe patterns observed in living organisms.
An assay (analysis) is never an isolated process, as it must be accompanied with pre- and post-analytic procedures. Both the communication order (the request to perform an assay plus related information) and the handling of the specimen itself (the collecting, documenting, transporting, and processing done before beginning the assay) are pre-analytic steps.
They also showed why lifespan scales as the + 1 ⁄ 4 power and heart rate as the - 1 ⁄ 4 power. Blood flow (+ 3 ⁄ 4) and resistance (-3 ⁄ 4) scale in the same way, leading to blood pressure being constant across species. [37] Hu and Hayton in 2001 discussed whether the basal metabolic rate scale is a 2 ⁄ 3 or 3 ⁄ 4 power of body mass.
procedures performed at the laboratory scale, which involve the sorts of procedures used in academic teaching and research laboratories in the training of chemists and in discovery chemistry venues in industry, [1] operations at the pilot plant scale, e.g., carried out by process chemists, which, though at the lowest extreme of manufacturing ...