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Diabetes mellitus, also known as type II diabetes, is a disease that affects over three million people in the U.S. per year. This disease affects the glucose levels in the body by causing them to rise higher than normal. In type II diabetic patients, the body develops insulin resistance that initiates an increase in blood glucose levels. [1]
Increased oxygen consumption during sustained exercise reduces the oxygen saturation of venous blood, which can reach less than 15% in a trained athlete; although breathing rate and blood flow increase to compensate, oxygen saturation in arterial blood can drop to 95% or less under these conditions. [28]
The needs of the body's blood oxygen may fluctuate such as during exercise when more oxygen is required [5] or when living at higher altitudes. A blood cell is said to be "saturated" when carrying a normal amount of oxygen. [6] Both too high and too low levels can have adverse effects on the body. [7]
Hypoxia can be due to external causes, when the breathing gas is hypoxic, or internal causes, such as reduced effectiveness of gas transfer in the lungs, reduced capacity of the blood to carry oxygen, compromised general or local perfusion, or inability of the affected tissues to extract oxygen from, or metabolically process, an adequate supply ...
Cardiovascular fitness can be assessed through various methods, including maximal oxygen uptake (V̇O 2max), which is the maximal amount of oxygen that can be used during exercise. Biomarkers , such as those used for assessing blood lipids , inflammation , glucose tolerance , and hemostasis , may be used to monitor progress during the ...
Venous blood with an oxygen concentration of 15 mL/100 mL would therefore lead to typical values of the a-vO 2 diff at rest of around 5 mL/100 mL. During intense exercise, however, the a-vO 2 diff can increase to as much as 16 mL/100 mL due to the working muscles extracting far more oxygen from the blood than they do at rest. [citation needed]
The Diabetes Research in Children Network Study Group observed blood sugar levels decrease rapidly in the first 15 minutes of exercise and continue to drop during the 75-minute session. [134] The Diabetes Research Group also found that after participating in prolonged aerobic exercise, 83% of participants had at least a 25% decrease in blood ...
Obesity has been found to contribute to approximately 55% of cases of type 2 diabetes; [10] chronic obesity leads to increased insulin resistance that can develop into type 2 diabetes, [11] most likely because adipose tissue (especially that in the abdomen around internal organs) is a source of several chemical signals, hormones and cytokines, to other tissues.
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