Search results
Results from the WOW.Com Content Network
In toxicology, the median lethal dose, LD 50 (abbreviation for "lethal dose, 50%"), LC 50 (lethal concentration, 50%) or LCt 50 is a toxic unit that measures the lethal dose of a given substance. [1] The value of LD 50 for a substance is the dose required to kill half the members of a tested population after a specified test duration.
For this reason, LD 50 figures are often qualified with the mode of administration, e.g., "LD 50 i.v." The related quantities LD 50 /30 or LD 50 /60 are used to refer to a dose that without treatment will be lethal to 50% of the population within (respectively) 30 or 60 days.
Trazodone is usually used at a dosage of 150 to 300 mg/day for the treatment of depression. [ 17 ] [ 13 ] Lower doses have also been used to augment other antidepressants or when initiating therapy. [ 17 ] [ 13 ] Higher doses, up to 600 mg/day, have been used in more severe cases of depression (in hospitalized patients, for example). [ 29 ]
The fixed-dose procedure (FDP), proposed in 1992 by the British Toxicology Society, is a method to assess a substance's acute oral toxicity. [ 1 ] [ 2 ] In comparison to the older LD 50 test developed in 1927, this procedure produces similar results while using fewer animals and causing less pain and suffering. [ 3 ]
The median toxic dose encompasses the category of toxicity that is greater than half maximum effective concentration (ED 50) but less than the median lethal dose (LD 50). However, for some highly potent toxins (ex. lofentanil , botulinum toxin ) the difference between the ED 50 and TD 50 is so minute that the values assigned to them may be ...
Benzodiazepine overdose (BZD OD) describes the ingestion of one of the drugs in the benzodiazepine class in quantities greater than are recommended or generally practiced. . The most common symptoms of overdose include central nervous system (CNS) depression, impaired balance, ataxia, and slurred spee
Most but not all values are for human proteins. These drugs act as antagonists or inverse agonists of the 5-HT 2A , α 1 -adrenergic, and H 1 receptors, as partial agonists of the 5-HT 1A receptor, [ 3 ] and as inhibitors of the transporters. mCPP is an antagonist of the 5-HT 2B receptor, an agonist of the 5-HT 1A , [ 3 ] 5-HT 2C , and 5-HT 3 ...
The median effective dose is the dose that produces a quantal effect (all or nothing) in 50% of the population that takes it (median referring to the 50% population base). [6] It is also sometimes abbreviated as the ED 50, meaning "effective dose for 50% of the population". The ED50 is commonly used as a measure of the reasonable expectancy of ...