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Cancer cells can also cause defects in the cellular pathways of apoptosis (programmed cell death). As most chemotherapy drugs kill cancer cells in this manner, defective apoptosis allows survival of these cells, making them resistant. Many chemotherapy drugs also cause DNA damage, which can be repaired by enzymes in the cell that carry out DNA ...
Most forms of chemotherapy target all rapidly dividing cells and are not specific to cancer cells, although some degree of specificity may come from the inability of many cancer cells to repair DNA damage, while normal cells generally can. Hence, chemotherapy has the potential to harm healthy tissue, especially those tissues that have a high ...
Chemotherapy can boost tumor immunity in two main ways: (a) by killing cancer cells through immunogenic cell death, and (b) by affecting both cancerous and normal cells in the tumor environment. Despite this, many chemotherapy treatments can also suppress the immune system by causing lymphopenia or impairing lymphocyte function. Integrating ...
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“The antibody can bind specifically to a target region, and once there is the binding, you can bring the chemotherapy into the cancer cells.” The approach also means that much more of the drug ...
Now, a study from Mass General Brigham has found that a combination of two types of therapeutic agents can selectively kill these breast cancer cells, raising hopes that this may lead to a new ...
In oncology, the fact that one round of chemotherapy does not kill all the cells in a tumor is a poorly understood phenomenon called fractional kill, or fractional cell kill. The fractional kill hypothesis states that a defined chemotherapy concentration, applied for a defined time period, will kill a constant fraction of the cells in a ...
Chemotherapy aims to kill cancer cells by attacking the cells that are in the process of doubling and dividing. ... a cancer hospital in London, chemotherapy can also be called “adjuvant therapy ...