Search results
Results from the WOW.Com Content Network
The Wiskott–Aldrich syndrome protein (WASp) is a 502-amino acid protein expressed in cells of the hematopoietic system that in humans is encoded by the WAS gene.In the inactive state, WASp exists in an autoinhibited conformation with sequences near its C-terminus binding to a region near its N-terminus.
Wiskott described three brothers with a similar disease, whose sisters were unaffected. In 2006, a German research group analyzed family members of Wiskott's three cases, and surmised they probably shared a novel frameshift mutation of the first exon of the WASp gene.
Neural Wiskott–Aldrich syndrome protein is a protein that in humans is encoded by the WASL gene. [ 5 ] [ 6 ] [ 7 ] The Wiskott–Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton .
The majority of the mutations causing Wiskott Aldrich Syndrome are located in the WH1 domain of WASp. [12] These mutations affect WASp-WIPF1 binding. [13] WIPF1 has an N-terminal profilin binding domain, two actin binding WH2 domains, a central polyproline stretch, and a C-terminal WASp Binding Domain. WASp protein is degraded in the absence of ...
This mutation causes the decreased, absent, or altered Wiskott–Aldrich syndrome protein (WASp). Normal WASp is involved in relaying signals from the cell membrane to the actin cytoskeleton. If WASp is decreased, absent, or altered, then the hematopoietic cells it is found in will show signaling and cytoskeleton abnormalities. [citation needed]
Wasps come in a variety of colors — from yellow and black to red and blue — and are split into two primary groups: social and solitary. Most wasps are solitary, non-stinging insects that do ...
The WH2 (WASP-Homology 2, or Wiskott–Aldrich homology 2) domain is an ~18 amino acids actin-binding motif. This domain was first recognized as an essential element for the regulation of the cytoskeleton by the mammalian Wiskott–Aldrich syndrome protein (WASP) family. WH2 proteins occur in eukaryotes from yeast to mammals, in insect viruses ...
Wiskott–Aldrich syndrome protein family member 1, also known as WASP-family verprolin homologous protein 1 (WAVE1), is a protein that in humans is encoded by the WASF1 gene. [ 5 ] [ 6 ] [ 7 ] Function