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Side effects such as ischemic brain necrosis and hearing loss are rare and proper fractionation protocol can prevent these effects from occurring; hypopituitarism has not been reported in cats, despite being a common adverse effect in humans. Survival times for cats after radiation therapy has been reported to be up to 5 years.
The US FDA has granted IntraBio a Rare Pediatric Disease Designation for N-Acetyl-Leucine for the treatment of GM2 Gangliosidosis. [ 12 ] Compassionate use studies in both Tay-Sachs and Sandhoff patients have demonstrated the positive clinical effects of treatment with N-Acetyl-Leucine for GM2 Gangliosidosis [ 13 ] These studies further ...
The post Apoquel for Cats: Uses, Dosage, & Side Effects appeared first on CatTime. ... since its introduction to the market in 2013, the drug’s efficacy in cats has been subject to extensive ...
The GM1 gangliosidoses, usually shortened to GM1, are gangliosidoses caused by mutation in the GLB1 gene resulting in a deficiency of beta-galactosidase.The deficiency causes abnormal storage of acidic lipid materials in cells of the central and peripheral nervous systems, but particularly in the nerve cells, resulting in progressive neurodegeneration.
A summary showing the causes of sphingolipidosis, including gangliosidosis. Gangliosides are also involved in several diseases: Influenza, in which haemagglutinin of influenza virus exploits certain gangliosides to enter and infect the cells expressing them.
Conservative treatment of arterial thromboembolism in cats is also based on this endogenous dissolution of the clot (see below). In cats, the blood clots originate mainly in the left atrial auricle. [8] They or parts of them are carried along with the blood flow, enter the aorta via the left ventricle, get stuck at vascular outlets and block them.
GM1 gangliosidosis are inherited disorders that progressively destroy neurons in the brain and spinal cord as GM1 accumulates. Without treatment, this results in developmental decline and muscle weakness, eventually leading to severe retardation and death.
Gangliosidosis contains different types of lipid storage disorders [1] caused by the accumulation of lipids known as gangliosides. There are two distinct genetic causes of the disease. There are two distinct genetic causes of the disease.