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  2. Interferon - Wikipedia

    en.wikipedia.org/wiki/Interferon

    For example, in January 2001, the Food and Drug Administration (FDA) approved the use of PEGylated interferon-alpha in the USA; in this formulation, PEGylated interferon-alpha-2b (Pegintron), polyethylene glycol is linked to the interferon molecule to make the interferon last longer in the body. Approval for PEGylated interferon-alpha-2a ...

  3. Interferon type I - Wikipedia

    en.wikipedia.org/wiki/Interferon_type_I

    The type-I interferons (IFN) are cytokines which play essential roles in inflammation, immunoregulation, tumor cells recognition, and T-cell responses. In the human genome, a cluster of thirteen functional IFN genes is located at the 9p21.3 cytoband over approximately 400 kb including coding genes for IFNα (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16 ...

  4. Enhanceosome - Wikipedia

    en.wikipedia.org/wiki/Enhanceosome

    The best known example of the enhanceosome acts on the human interferon-beta gene, which is upregulated in cells that are infected by viruses. [5] Three activator proteins— NF-κB , an interferon activator protein such as IRF-3 , and the ATF -2/c-Jun complex—cooperatively bind to the upstream enhancer region upon viral infection.

  5. IFNA2 - Wikipedia

    en.wikipedia.org/wiki/IFNA2

    The gene encoding IFNα2, the IFNA2 gene, is clustered with all other type I IFN genes on chromosome 9 [8] and as all type I IFN genes, it is devoid of intron. [9] The open reading frame (coding sequence) of IFNA2 codes for a pre-protein of 188 amino acids with a 23 amino acid signal peptide allowing secretion of the mature protein.

  6. Interferon-alpha/beta receptor - Wikipedia

    en.wikipedia.org/wiki/Interferon-alpha/beta_receptor

    The interferon-α/β receptor (IFNAR) is a virtually ubiquitous membrane receptor which binds endogenous type I interferon (IFN) cytokines. Endogenous human type I IFNs include many subtypes, such as interferons-α, -β, -ε, -κ, -ω, and -ζ.

  7. Interferon-stimulated gene - Wikipedia

    en.wikipedia.org/wiki/Interferon-stimulated_gene

    An interferon-stimulated gene (ISG) is a gene that can be expressed in response to stimulation by interferon. [1] [2] Interferons bind to receptors on the surface of a cell, initiating protein signaling pathways within the cell. This interaction leads to the expression of a subset of genes involved in the innate immune system response. [1]

  8. Interferon alpha-1 - Wikipedia

    en.wikipedia.org/wiki/Interferon_alpha-1

    n/a Ensembl ENSG00000197919 n/a UniProt P01562 n/a RefSeq (mRNA) NM_024013 n/a RefSeq (protein) NP_076918 n/a Location (UCSC) Chr 9: 21.44 – 21.44 Mb n/a PubMed search n/a Wikidata View/Edit Human Interferon alpha-1 is a protein that in humans is encoded by the IFNA1 gene. Leukocyte interferon is produced predominantly by B lymphocytes. Immune interferon (IFN-gamma ; MIM 147570) is produced ...

  9. IFNB1 - Wikipedia

    en.wikipedia.org/wiki/IFNB1

    Interferon beta is a protein that in humans is encoded by the IFNB1 gene. [5] The natural and recombinant protein forms have antiviral, antibacterial, and anticancer properties. Interferon beta 1a (tradenames: Avonex and Rebif) and Interferon beta 1b (tradenames: Betaseron/Betaferon) are used as drugs.