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[96] [97] At high doses, statins have anti-inflammatory effects, incite reduction of the necrotic plaque core, and improve endothelial function, leading to plaque stabilization and, sometimes, plaque regression. [97] [96] There is a similar thought process with using high-dose atorvastatin as a form of secondary thrombotic stroke recurrence ...
Guidelines by the American College of Cardiology and the American Heart Association recommend statin treatment for primary prevention of cardiovascular disease in adults with LDL cholesterol ≥ 190 mg/dL (4.9 mmol/L) or those with diabetes, age 40–75 with LDL-C 70–190 mg/dL (1.8–4.9 mmol/dL); or in those with a 10-year risk of developing ...
In studies using standard doses, statins have been found to lower LDL-C by 18% to 55%, depending on the specific statin being used. A risk exists of muscle damage (myopathy and rhabdomyolysis) with statins. Hypercholesterolemia is not a risk factor for mortality in persons older than 70 years and risks from statin drugs are more increased after ...
At the time, the RDD of rosuvastatin was similar to its DDD (12.6 mg vs 10mg), but the RDD of atorvastatin was twice its DDD (20.6 mg vs 10mg). The DDD of atorvastatin was revised in 2009 to 20mg. [4] The Canadian Patented Medicine Prices Review Board analysed the use of DDD for drug utilisation and cost analysis and offered recommendations ...
Fluzone High-Dose flu vaccine. The Fluzone High-Dose vaccine, manufactured by Sanofi, contains four times the protection of standard-dose vaccines. Medicare Part B, most Medicare Advantage plans ...
These high dose vaccines help boost immune response in older adults. Infectious disease experts say the optimal time to receive both the flu vaccine and updated COVID-19 vaccine is late September ...
Avonex and atorvastatin: Avonex (beta-1a) has also been combined with atorvastatin in a clinical trial showing that is safe in its conditions, [133] even though high-dose statins are expected to produce liver problems and muscle-wasting disease over the long-term. [134] Other clinical trials have found problems combining IFN beta with ...
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