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Cyproheptadine, sold under the brand name Periactin among others, is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. It was patented in 1959 and came into medical use in 1961. [ 5 ]
All three of these agents, pizotifen, cyproheptadine, and clozapine act as non-selective monoamine receptor antagonists. [10] Pizotifen also fully blocks the effects of serotonergic psychedelics , including LSD , mescaline , 5-MeO-DMT , and DOM , in drug discrimination tests.
The serotonin antagonist cyproheptadine is the recommended initial therapy, although there have been no controlled trials demonstrating its efficacy for SS. [ 9 ] [ 69 ] [ 70 ] Despite the absence of controlled trials, there are a number of case reports detailing apparent improvement after people have been administered cyproheptadine. [ 9 ]
After chronic dosing of cyproheptadine (a rather high dose of 8-12mg for 5 days... typical doses are 2-4mg), it reduced growth hormone by over 50%. —Preceding unsigned comment added by 204.111.160.135 20:03, 28 April 2009 (UTC) I have added the reference and data to the adverse effects section of the article.
Apetamin is a potentially dangerous figure-augmentation product. [1] [2] It is a syrup containing cyproheptadine, the amino acid lysine, and some vitamins.Cyproheptadine, the active ingredient, is an antihistamine and a hepatotoxin that has many effects on the body, including increased appetite, fatigue, and drowsiness. [3]
[17] [4] It also has functional antiandrogenic effects by decreasing the circulating free fractions of androgens. [18] CPA is a progestin (synthetic progestogen ), or an agonist of the progesterone receptors , the biological target of progestogens like progesterone .
Cyproterone, also known by its developmental code name SH-80881, is a steroidal antiandrogen which was studied in the 1960s and 1970s but was never introduced for medical use.
These concerns and others led to a revamping of the Music Key concept to create YouTube Red; unlike Music Key, YouTube Red was designed to provide ad-free streaming to all videos, rather than just music content. This shift required YouTube to seek permission from its content creators and rights holders to allow their content to be part of the ...