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Left untreated, vitamin B12 deficiencies can lead to serious health problems including neurological problems and anemia. [89] Although more research is needed to understand the mechanisms of this association, it is suggested that people who take metformin monitor their vitamin B12 levels and if low, begin supplementation. [88]
Metformin reduces intestinal absorption of vitamin B12 and also serum vitamin B12 concentration, thus patients are recommended to monitor B12 deficiency with complete blood count. [36] Regarding breastfeeding, metformin does not show obvious association with adverse outcomes. [ 37 ]
A large number of pregnant women have been found to have low levels of vitamin B12, but supplementation has not yet been shown to improve pregnancy outcome or the health of the newborn. [ 12 ] Long-chain polyunsaturated fatty acids, specifically docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are beneficial for fetal development.
Experts say that metformin and insulin can also be used together to help women with type 2 diabetes and gestational diabetes manage blood glucose levels during pregnancy. Metformin is just as safe ...
[1] [6] Temporary infertility, reversible with treatment, may occur. [1] [7] A late finding type of anemia known as megaloblastic anemia is often but not always present. [2] In exclusively breastfed infants of vegan mothers, undetected and untreated deficiency can lead to poor growth, poor development, and difficulties with movement. [2]
Liquid metformin is typically taken with meals once or twice a day. The same advice goes here, too: If you take metformin twice or three times a day, aim to take it at the same times each day ...
Among the 199 participants, 154 took a daily dose of up to 2,500mg of metformin for six months — the average metformin dose was 2,230mg daily. The remaining 45 participants weren’t treated ...
[39]: 973 Breast milk B 12 decreases over months of nursing in both well-nourished and vitamin-deficient mothers. [39]: 973–974 Exclusive or near-exclusive breastfeeding beyond six months is a strong indicator of low serum vitamin status in nursing infants. This is especially true when the vitamin status is poor during the pregnancy and if ...