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Estrogen deprivation therapy, also known as endocrine therapy, is a form of hormone therapy that is used in the treatment of breast cancer.Modalities include antiestrogens or estrogen blockers such as selective estrogen receptor modulators (SERMs) like tamoxifen, selective estrogen receptor degraders like fulvestrant, and aromatase inhibitors like anastrozole and ovariectomy.
Aromatase inhibitors, which stop the production of estrogen in postmenopausal women, have become useful in the management of patients with breast cancer whose lesion was found to be estrogen receptor positive. [33] Inhibitors that are in current clinical use include anastrozole, exemestane, and letrozole.
But as I mentioned before, hormone receptor–positive is the most common type of breast cancer, and when you undergo endocrine therapy, you’re trying to stop estrogen production.
Antiestrogens, also known as estrogen antagonists or estrogen blockers, are a class of drugs which prevent estrogens like estradiol from mediating their biological effects in the body. They act by blocking the estrogen receptor (ER) and/or inhibiting or suppressing estrogen production .
The ovaries also stop making estrogen, a hormone that helps to control the menstrual cycle, according to the American College of Obstetricians and Gynecologists (ACOG). The average age that women ...
One study found that thyroid disorders, such as hypothyroidism (low thyroid hormone production), may decrease the production of estrogen and other hormones. However, the above study's sample size ...
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