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Acute liver failure is the appearance of ... Causes of death for the 101 patients who died within the 3-week period included cerebral edema, multiorgan failure ...
Cerebral edema is commonly seen in a variety of brain injuries including ischemic stroke, subarachnoid hemorrhage, traumatic brain injury, subdural, epidural, or intracerebral hematoma, hydrocephalus, brain cancer, brain infections, low blood sodium levels, high altitude, and acute liver failure.
Coma and seizures represent the most advanced stage; cerebral edema (swelling of the brain tissue) leads to death. [ 4 ] Encephalopathy often occurs together with other symptoms and signs of liver failure.
Classification for hepatic insufficiency. In hyperacute and acute liver failure, the clinical picture develops rapidly with progressive encephalopathy and multiorgan dysfunction such as hyperdynamic circulation, coagulopathy, acute kidney injury and respiratory insufficiency, severe metabolic alterations, and cerebral edema that can lead to brain death.
Reye syndrome is a rapidly worsening brain disease. [2] Symptoms of Reye syndrome may include vomiting, personality changes, confusion, seizures, and loss of consciousness. [1] While liver toxicity typically occurs in the syndrome, jaundice usually does not. [2]
Generalized brain swelling can occur in ischemic-anoxia states, acute liver failure, [9] hypertensive encephalopathy, hypercarbia (hypercapnia), and Reye hepatocerebral syndrome. These conditions tend to decrease the cerebral perfusion pressure but with minimal tissue shifts.
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Clinical signs of cerebral edema, such as focal neurological deficits, papilledema [5] and decreased level of consciousness, if temporally associated with recent hemodialysis, suggest the diagnosis. A computed tomography of the head is typically done to rule-out other intracranial causes.
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