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Contrast-induced nephropathy (CIN) is a purported form of kidney damage in which there has been recent exposure to medical imaging contrast material without another clear cause for the acute kidney injury. Despite extensive speculation, the actual occurrence of contrast-induced nephropathy has not been demonstrated in the literature. [1]
The reasoning is that if the contrast medium causes kidney failure (as happens rarely) and the person continues to take metformin (which is normally excreted by the kidneys), there may be a toxic accumulation of metformin, increasing the risk of lactic acidosis, a dangerous complication. [31]
Radioisotope renography is a form of medical imaging of the kidneys that uses radiolabelling.A renogram, which may also be known as a MAG3 scan, allows a nuclear medicine physician or a radiologist to visualize the kidneys and learn more about how they are functioning. [1]
All patients are reviewed for contraindications prior to MRI scanning. Medical devices and implants are categorized as MR Safe, MR Conditional or MR Unsafe: [6] MR-Safe – The device or implant is completely non-magnetic, non-electrically conductive, and non-RF reactive, eliminating all of the primary potential threats during an MRI procedure.
MRI contrast agents may be administered by injection into the blood stream or orally, depending on the subject of interest. Oral administration is well suited to gastrointestinal tract scans, while intravascular administration proves more useful for most other scans. MRI contrast agents can be classified [2] by their: Chemical composition
Intravenous digital subtraction angiography (IV-DSA) is a form of angiography which was first developed in the late 1970s.. IV-DSA is a computer technique that compares an X-ray image of a region of the body before and after radiopaque iodine based dye has been injected intravenously into the body.
Magnetic resonance imaging (MRI) is recommended instead of CT for patients with an allergy to iodinated contrast materials. [8] As some renal tumors do not enhance significantly on CT, MRI examination is required to be performed with more sensitive contrast enhancement. [ 7 ]
The kidney is surrounded by a capsule separating the kidney from the echogenic perirenal fat, which is seen as a thin linear structure. [1] The kidney is divided into parenchyma and renal sinus. The renal sinus is hyperechoic and is composed of calyces, the renal pelvis, fat and the major intrarenal vessels.