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  2. Interleukin 13 - Wikipedia

    en.wikipedia.org/wiki/Interleukin_13

    The secondary structural features of IL-13 are similar to that of Interleukin 4 (IL-4); however it only has 25% sequence identity to IL-4 and is capable of IL-4 independent signaling. [ 7 ] [ 4 ] [ 8 ] IL-13 is a cytokine secreted by T helper type 2 (Th2) cells, CD4 cells, natural killer T cell , mast cells , basophils , eosinophils and ...

  3. List of therapeutic monoclonal antibodies - Wikipedia

    en.wikipedia.org/wiki/List_of_therapeutic...

    When used as drugs, the International Nonproprietary Names (INNs) end in -mab. The remaining syllables of the INNs, ... IL-13: Abrilumab [6] mab: human: integrin ...

  4. Interleukin - Wikipedia

    en.wikipedia.org/wiki/Interleukin

    Interleukin 13 (IL-13) is a pleiotropic cytokine that may be important in the regulation of the inflammatory and immune responses. [40] It inhibits inflammatory cytokine production and synergises with IL-2 in regulating interferon-gamma synthesis. The sequences of IL-4 and IL-13 are distantly related. [41]

  5. Interleukin 13 receptor, alpha 1 - Wikipedia

    en.wikipedia.org/wiki/Interleukin_13_receptor...

    Interleukin 13 receptor, alpha 1, also known as IL13RA1 and CD213A1 (cluster of differentiation 213A1), is a human gene. [5] The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors.

  6. Pitrakinra - Wikipedia

    en.wikipedia.org/wiki/Pitrakinra

    It is an IL-4 and IL-13 antagonist that has been studied in a phase IIb clinical trial for the treatment of asthma. Two point mutations on pitrakinra (position 121 mutated from arginine to aspartic acid and position 124 mutated from tyrosine to aspartic acid) confer its ability to block signaling of IL-4 and interleukin-13 (IL-13) by preventing ...

  7. Interleukin-13 receptor - Wikipedia

    en.wikipedia.org/wiki/Interleukin-13_receptor

    The interleukin-13 receptor is a type I cytokine receptor, binding Interleukin-13.It consists of two subunits, encoded by IL13RA1 and IL4R, respectively. [1] [2] These two genes encode the proteins IL-13Rα1 and IL-4Rα.

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  9. Infliximab - Wikipedia

    en.wikipedia.org/wiki/Infliximab

    Infliximab, a chimeric monoclonal antibody, sold under the brand name Remicade among others, is a medication used to treat a number of autoimmune diseases.This includes Crohn's disease, ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, and Behçet's disease. [23]

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