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There are numerous causes of palpable purpura, such as autoimmune diseases, drug reactions, vaccinations, and infections.The most common infectious causes are N. gonorrhoeae, S. aureus, and N. meningitides, however palpable purpura has also been caused by Mycoplasma spp., Rickettsiae, Mycobacterium, and very rarely by Treponema pallidum, Brucella spp., Yersinia, Campylobacter, and Bartonella.
IgA vasculitis (HSP), previously known as Henoch–Schönlein purpura, is a disease of the skin, mucous membranes, and sometimes other organs that most commonly affects children. In the skin, the disease causes palpable purpura (small, raised areas of bleeding underneath the skin), often with joint pain and abdominal pain.
Once fully developed, the classic appearance is "non-blanching, palpable purpura". [6] [5] [7] This appears as deep red to purple spots that feel raised to the touch. Purpura refers to the red-purple discolored spots, while palpable implies that these spots can be felt as raised from the surrounding skin.
Purpura (/ ˈ p ɜːr p jʊər ə / [1]) is a condition of red or purple discolored spots on the skin that do not blanch on applying pressure. The spots are caused by bleeding underneath the skin secondary to platelet disorders, vascular disorders, coagulation disorders, or other causes. [ 2 ]
Such lesions include petechia (less than 3 mm (0.12 in), resulting from numerous and diverse etiologies such as adverse reactions from medications such as warfarin, straining, asphyxiation, platelet disorders and diseases such as cytomegalovirus); [6] and purpura (3–10 mm (0.12–0.39 in)), classified as palpable purpura or non-palpable ...
Rheumatoid vasculitis can cause palpable purpura, ulcers, nodules, and digital necrosis on the skin. [6] Even though it is nonspecific and present in many different disorders, livedo reticularis is frequently observed. [3] Peripheral nervous system involvement is the second most common organ involved.
Although it causes fever, large palpable purpuric skin lesions, and edema, it is a harmless condition. AHEI's appearance is frequently similar to that of Henoch-Schönlein purpura. Because AHEI is a self-limiting disease, conservative treatment is common. [2] Snow described acute hemorrhagic edema of infancy in the United States in 1913.
Vasculitis is a group of disorders that destroy blood vessels by inflammation. [2] Both arteries and veins are affected. Lymphangitis (inflammation of lymphatic vessels) is sometimes considered a type of vasculitis. [3]