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Phenytoin may accumulate in the cerebral cortex over long periods of time which can cause atrophy of the cerebellum. The degree of atrophy is related to the duration of phenytoin treatment and is not related to dosage of the medication. [23] Phenytoin is known to be a causal factor in the development of peripheral neuropathy. [24]
Anticonvulsants are also increasingly being used in the treatment of bipolar disorder [2] [3] and borderline personality disorder, [4] since many seem to act as mood stabilizers, and for the treatment of neuropathic pain. [5] Anticonvulsants suppress the excessive rapid firing of neurons during seizures. [6]
Trigeminal neuralgia (TN or TGN), also called Fothergill disease, tic douloureux, trifacial neuralgia, or suicide disease, is a long-term pain disorder that affects the trigeminal nerve, [7] [1] the nerve responsible for sensation in the face and motor functions such as biting and chewing.
Jackie Galgey, 45, shares in a personal essay her experience with trigeminal neuralgia, also called the suicide disease, which caused her one-sided facial pain.
Acute pain due to trigeminal neuralgia is usually successfully treated with anticonvulsants such as carbamazepine [155] or phenytoin. [156] [157] [158] Both Lhermitte's sign and painful dysesthesias usually respond to treatment with carbamazepine, clonazepam, [159] or amitriptyline.
Typically, dementia is associated with classic symptoms like confusion and memory loss. But new research finds that there could be a less obvious risk factor out there: your cholesterol levels ...
The trigeminal nerve.. ATN is usually attributed to inflammation or demyelination, with increased sensitivity of the trigeminal nerve.These effects are believed to be caused by infection, demyelinating diseases, or compression of the trigeminal nerve (by an impinging vein or artery, a tumor, dental trauma, accidents, or arteriovenous malformation) and are often confused with dental problems.
[4] [18] Carbamazepine is the only medication that is approved by the Food and Drug Administration for the treatment of trigeminal neuralgia. [ 19 ] As of 2014, a controlled release formulation was available for which there is tentative evidence showing fewer side effects and unclear evidence with regard to whether there is a difference in ...
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