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Corticobasal degeneration (CBD) is a rare neurodegenerative disease involving the cerebral cortex and the basal ganglia. [1] CBD symptoms typically begin in people from 50 to 70 years of age, and typical survival before death is eight years.
Corticobasal syndrome (CBS) is a rare, progressive atypical Parkinsonism syndrome and is a tauopathy related to frontotemporal dementia. [ 1 ] [ 2 ] CBS is typically caused by the deposit of tau proteins forming in different areas of the brain.
They include multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD). Dementia with Lewy bodies (DLB), may or may not be part of the PD spectrum, but it is increasingly recognized as the second-most common type of neurodegenerative dementia after Alzheimer's disease.
Corticobasal degeneration (CBD) is an increasingly acknowledged neurodegenerative disorder characterized by both motor and cognitive dysfunction. In affected regions, histological examination reveals pronounced neuronal loss accompanied by spongiosis and gliosis, cortical ballooned cells, and notable intracytoplasmic filamentous tau pathology ...
Corticobasal degeneration; ... Hereditary motor and sensory neuropathy with proximal dominance; I. ... Subacute combined degeneration of spinal cord;
Corticobasal degeneration; Cotard delusion; Cranial arteritis; Craniosynostosis; Creutzfeldt–Jakob disease; Cumulative trauma disorders; Cushing's syndrome; Cyclic vomiting syndrome; Cyclothymic disorder; Cytomegalic inclusion body disease; Cytomegalovirus Infection
Hereditary diffuse leukoencephalopathy with spheroids is inherited in an autosomal dominant manner Hereditary diffuse leukoencephalopathy with spheroids ( HDLS ) is a rare adult onset autosomal dominant disorder characterized by cerebral white matter degeneration with demyelination and axonal spheroids leading to progressive cognitive and motor ...
The most severe brain atrophy appears to be associated with behavioral variant FTD, and corticobasal degeneration. [42] With regard to the genetic defects that have been found, repeat expansion in the C9orf72 gene is considered a major contribution to FTLD, although defects in the GRN and MAPT genes are also associated with it. [43]