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Antihistamines are drugs which treat allergic rhinitis, common cold, influenza, and other allergies. [1] Typically, people take antihistamines as an inexpensive, generic (not patented) drug that can be bought without a prescription and provides relief from nasal congestion, sneezing, or hives caused by pollen, dust mites, or animal allergy with few side effects. [1]
It is a second-generation H1-receptor antagonist antihistamine (like its base molecule triprolidine) and works by blocking histamine H1 receptors. [ 1 ] This non-sedating [ verification needed ] antihistamine is sold under the brand name Benadryl Allergy Relief in the United Kingdom by McNeil Laboratories .
Doxepin is a highly potent antihistamine, with this being its strongest activity. [ 49 ] [ 53 ] [ 57 ] [ 8 ] In fact, doxepin has been said to be the most or one of the most potent H 1 receptor antagonists available, with one study finding an in vitro K i of 0.17 nM. [ 37 ]
Loratadine is a tricyclic antihistamine, which acts as a selective inverse agonist of peripheral histamine H 1 receptors. [ 22 ] [ 26 ] The potency of second generation histamine antagonists is (from strongest to weakest) desloratadine ( K i 0.4 nM) > levocetirizine (K i 3 nM) > cetirizine (K i 6 nM) > fexofenadine (K i 10 nM) > terfenadine ...
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Doxylamine and other first-generation antihistamines are the most widely used sleep medications in the world. [6] Typical side effects of doxylamine (at recommended doses) include dizziness, drowsiness, grogginess, and dry mouth, among others. [7] [4] As an antihistamine, doxylamine is an inverse agonist of the histamine H 1 receptor.
A review that considered berberine’s effects on heart health found some studies supporting this claim, but due to the high risk of bias, the researchers recommended more clinical trials be ...
Experts explain whether ice or heat for back pain will lead to better relief, and the best time to use each.
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