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Wolfram syndrome, also called DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness), is a rare autosomal-recessive genetic disorder that causes childhood-onset diabetes mellitus, optic atrophy, and deafness as well as various other possible disorders including neurodegeneration.
The number of new cases of diabetes insipidus each year is 3 in 100,000. [4] Central DI usually starts between the ages of 10 and 20 and occurs in males and females equally. [2] Nephrogenic DI can begin at any age. [3] The term "diabetes" is derived from the Greek word meaning siphon. [6]
Untreated central diabetes insipidus patients usually exhibit polyuria, nocturia, and polydipsia as a result of the initial rise of serum sodium and osmolality. [5] Patients may also experience neurologic symptoms associated with the underlying illness, such as headaches and diplopia, depending on the exact origin of the central diabetes insipidus.
Research shows that making healthy lifestyle changes can significantly reduce your risk of progressing to type 2 diabetes. But with so much conflicting information online, knowing what healthy ...
Prediabetes, often considered the step before diabetes, is when you have higher than usual blood glucose (blood sugar) levels. Your levels aren’t high enough to be classified as type 2 diabetes.
A fluid or water deprivation test is a medical test [1] which can be used to determine whether the patient has diabetes insipidus as opposed to other causes of polydipsia (a condition of excessive thirst that causes an excessive intake of water). The patient is required, for a prolonged period, to forgo intake of water completely, to determine ...
The diabetes that accompanies the hearing loss can be similar to Type 1 diabetes or Type 2 diabetes; however, Type 1-like diabetes is the more common form of the two. MIDD has also been associated with a number of other issues including kidney dysfunction, gastrointestinal problems , and cardiomyopathy .
Maturity-onset diabetes of the young: MOH Medication overuse headaches: MPD Myeloproliferative disorders: MPS I Mucopolysaccharoidosis type I (see Hurler syndrome) MPS II Mucopolysaccharoidosis type II (see Hunter syndrome) MPS III Mucopolysaccharoidosis type III (see Sanfilippo syndrome) MPS IV Mucopolysaccharoidosis type IV (see Morquio syndrome)