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  2. Cetuximab - Wikipedia

    en.wikipedia.org/wiki/Cetuximab

    Cetuximab, sold under the brand name Erbitux, is an epidermal growth factor receptor (EGFR) inhibitor medication used for the treatment of metastatic colorectal cancer and head and neck cancer. [2] Cetuximab is a chimeric (mouse/human) monoclonal antibody given by intravenous infusion .

  3. Abigail Alliance for Better Access to Developmental Drugs v ...

    en.wikipedia.org/wiki/Abigail_Alliance_for...

    Abigail Burroughs was a college student diagnosed with head and neck cancer. During the later phases of her treatment, Abigail's father, Frank Burroughs, formed an organization, the Abigail Alliance for Better Access to Developmental Drugs and sued the FDA for access to Erbitux.

  4. John Mendelsohn (doctor) - Wikipedia

    en.wikipedia.org/wiki/John_Mendelsohn_(doctor)

    Antibody 225 (commercially known as Cetuximab, or Erbitux) against the receptor for epidermal growth factor was approved by the United States Food and Drug Administration for treatment of colon cancer in 2004 and for head and neck cancer in 2006.

  5. Passive antibody therapy - Wikipedia

    en.wikipedia.org/wiki/Passive_antibody_therapy

    Cetuximab (trade name: Erbitux ) is a recombinant chimeric monoclonal antibody designed to treat metastatic colorectal cancer and head and neck cancer. [14] In numerous cancers, the epidermal growth factor receptor (EGFR) is often inappropriately activated and overexpressed in cancer cells, leading to uncontrolled cell growth. [15]

  6. List of antineoplastic agents - Wikipedia

    en.wikipedia.org/wiki/List_of_antineoplastic_agents

    Cetuximab: IV: EGFR inhibitor. Squamous cell head and neck cancer or EGFR-positive and KRAS wild-type metastatic colorectal cancer. Infusion-related reactions, skin ...

  7. Epidermal growth factor receptor - Wikipedia

    en.wikipedia.org/wiki/Epidermal_growth_factor...

    The identification of EGFR as an oncogene has led to the development of anticancer therapeutics directed against EGFR (called "EGFR inhibitors", EGFRi), including gefitinib, [28] erlotinib, [29] afatinib, brigatinib and icotinib [30] [31] for lung cancer, and cetuximab for colon cancer.

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  9. Head and neck cancer - Wikipedia

    en.wikipedia.org/wiki/Head_and_neck_cancer

    Globally, head and neck cancer accounts for 650,000 new cases of cancer and 330,000 deaths annually on average. In 2018, it was the seventh most common cancer worldwide, with 890,000 new cases documented and 450,000 people dying from the disease. [12] The risk of developing head and neck cancer increases with age, especially after 50 years.

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