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Tinidazole, sold under the brand name Tindamax among others, is a medication used against protozoan infections. It is widely known throughout Europe and the developing world as a treatment for a variety of anaerobic amoebic and bacterial infections. It was developed in 1972 and is a prominent member of the nitroimidazole antibiotic class. [2]
Metronidazole, or a related drug such as tinidazole, secnidazole or ornidazole, is used to destroy amoebae that have invaded tissue. [2] These are rapidly absorbed into the bloodstream and transported to the site of infection. Because they are rapidly absorbed there is almost none remaining in the intestine.
The evidence for comparing metronidazole to other alternatives such as mebendazole, tinidazole, or nitazoxanide was felt to be of very low quality. [60] While tinidazole has side effects and efficacy similar to those of metronidazole, it is administered with a single dose.
ATC code J01 Antibacterials for systemic use is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
A 14-day course of "quadruple therapy" with a proton pump inhibitor, bismuth, tetracycline, and metronidazole or tinidazole is a more complicated but also more effective regimen. In a 2011 randomized, controlled trial, the per protocol eradication rates were 93% with quadruple therapy and 70% with triple therapy.
In those with Giardia species or Entamoeba histolytica, tinidazole treatment is recommended and superior to metronidazole. [36] [76] The World Health Organization (WHO) recommends the use of antibiotics in young children who have both bloody diarrhea and fever. [1]
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Perhaps the most common example is metronidazole. Other heterocycles such as nitrothiazoles are also used for this purpose. Nitroheterocycles may be reductively activated in hypoxic cells, and then undergo redox recycling or decompose to toxic products. [5] Three nitroimidazole antibiotics: metronidazole, tinidazole, and nimorazole
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