Search results
Results from the WOW.Com Content Network
The most obvious, first effects (gingival and hair problems) of absence of ascorbic acid in humans come from the resulting defect in hydroxylation of proline residues of collagen, with reduced stability of the collagen molecule, causing scurvy. Increased serum and urine levels of hydroxyproline have also been demonstrated in Paget's disease. [10]
Hyperprolinemia type II results in proline levels in the blood between 10 and 15 times higher than normal, and high levels of a related compound called pyrroline-5-carboxylate. This rare form of the disorder may appear benign at times, [ 2 ] but often involves seizures, convulsions, and intellectual disability.
Unlike systemin, it is primarily associated with the cell wall. The precursors to HypSys appear to represent a distinct subfamily of hydroxyproline-rich proteins found in cell walls. Upon wounding it is thought that a protease from the cytosol, the cell wall matrix, or the pathogen, processes the precursor producing active HypSys peptides. [13]
Procollagen-proline dioxygenase catalyzes the following reaction: L-proline + alpha-ketoglutaric acid + O 2 → (2S, 4R)-4-hydroxyproline + succinate + CO 2. The mechanism for the reaction is similar to that of other dioxygenases, and occurs in two distinct stages: [3] In the first, a highly reactive Fe(IV)=O species is produced.
Low testosterone can negatively impact sexual function, mood, energy level, muscle mass, and weight, according to Javaid. ... but a growing body of research is finding little negative effect on ...
Collagen, the most prevalent protein in the human body, is necessary for maintaining strong connective tissues, cellular proliferation, and wound healing, among other functions. [17] As collagen is degraded, dipeptides are released as a byproduct. Serum prolidase absorbs and digests these byproducts so they can be reused in collagen production. [8]
Healthy meals provide fuel for cells. Too much added sugar in the diet can overwhelm cells and slow down the activities inside them, causing 'traffic jams' that can lead to chronic disease ...
A recent study by the University of Southern California revealed that exposure to air pollution can harm children's learning and memory, the LA Post reports. Ammonium nitrate, a specific component ...