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Most of erythromycin is metabolised by demethylation in the liver by the hepatic enzyme CYP3A4. Its main elimination route is in the bile with little renal excretion, 2%–15% unchanged drug. Erythromycin's elimination half-life ranges between 1.5 and 2.0 hours and is between 5 and 6 hours in patients with end-stage renal disease. Erythromycin ...
The erythromycin breath test has numerous clinical applications, particularly in transplantation and pharmacology. It is frequently used to evaluate the activity of the CYP3A4 enzyme, which is critical in the metabolism of medications such as cyclosporine and tacrolimus in liver transplant patients.
In addition, the efficacy of doxycycline and erythromycin succinate may be reduced by alcohol consumption. [64] Other effects of alcohol on antibiotic activity include altered activity of the liver enzymes that break down the antibiotic compound. [29]
However, he questioned if it was a rare genetic condition called Gaucher disease, which involves a buildup of fatty cells in the liver, spleen, and occasionally the bone marrow. (This happens ...
Macrolides, mainly erythromycin and clarithromycin, also have a class effect of QT prolongation, which can lead to torsades de pointes. Macrolides exhibit enterohepatic recycling; that is, the drug is absorbed in the gut and sent to the liver, only to be excreted into the duodenum in bile from the liver. This can lead to a buildup of the ...
Cost: $56.00 for 2oz tub | Key Ingredients: Calendula Oil, Ginger Oil, Menthol Crystals, Pineapple Enzymes (Bromelain), ... The cream contains 10% trolamine salicylate, a topical pain reliever ...
1576 n/a Ensembl ENSG00000160868 n/a UniProt P08684 n/a RefSeq (mRNA) NM_001202855 NM_001202856 NM_001202857 NM_017460 n/a RefSeq (protein) NP_001189784 NP_059488 n/a Location (UCSC) Chr 7: 99.76 – 99.78 Mb n/a PubMed search n/a Wikidata View/Edit Human Cytochrome P450 3A4 (abbreviated CYP3A4) (EC 1.14.13.97) is an important enzyme in the body, mainly found in the liver and in the intestine ...
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