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It is strongly dose-dependent: for the immediate release preparation, the seizure incidence is 0.4% at the dose 300–450 mg per day; the incidence climbs almost ten-fold for the higher than recommended dose of 600 mg. [10] [11] For comparison, the incidence of unprovoked seizure in the general population is 0.07–0.09%, and the risk of ...
[4] [8] Both standard clinical doses of oral selegiline (up to 10 mg/day) and higher doses of oral selegiline (e.g., 30 to 60 mg/day) have been used to treat depression, with the lower doses selectively inhibiting MAO-B and the higher doses producing dual inhibition of both MAO-A and MAO-B. [9] [24] Unlike oral selegiline, transdermal ...
SB-649,915 is a serotonin reuptake inhibitor and 5-HT 1A and 5-HT 1B receptor antagonist which is being investigated for its antidepressant effects. [1] Relative to the selective serotonin reuptake inhibitors (SSRIs), SB-649,915 has a faster onset of action and may also have greater clinical efficacy as well. [1]
Methylphenidate, sold under the brand names Ritalin (/ ˈ r ɪ t ə l ɪ n / RIT-ə-lin) and Concerta (/ k ə n ˈ s ɜːr t ə / kən-SUR-tə) [citation needed] among others, is a FDA-approved central nervous system (CNS) stimulant to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy.
Honda issued a recall that covers 720,810 vehicles due to a potential issue with the fuel pump. The production issue may lead to cracks forming on the solenoid component of the fuel pump, which ...
Methylene blue is a monoamine oxidase inhibitor (MAOI) [51] and, if infused intravenously at doses exceeding 5 mg/kg, may result in serotonin syndrome if combined with any selective serotonin reuptake inhibitors (SSRIs) or other serotonergic drugs (e.g., duloxetine, sibutramine, venlafaxine, clomipramine, imipramine).
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Conversely, in studies of healthy men given high-dose spironolactone, gynecomastia occurred in 3 of 10 (30%) at 100 mg/day, in 5 of 8 (62.5%) at 200 mg/day, and in 6 of 9 (66.7%) at 400 mg/day, relative to none of 12 controls. [134] [135] The severity of gynecomastia with spironolactone varies considerably, but is usually mild. [110]
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