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When BAD is phosphorylated by Akt/protein kinase B (triggered by PIP 3), it forms the BAD- protein heterodimer. This leaves Bcl-2 free to inhibit Bax-triggered apoptosis. [9] BAD phosphorylation is thus anti-apoptotic, and BAD dephosphorylation (e.g., by Ca 2+-stimulated Calcineurin) is pro-apoptotic. The latter may be involved in neural ...
596 12043 Ensembl ENSG00000171791 ENSMUSG00000057329 UniProt P10415 P10417 RefSeq (mRNA) NM_000633 NM_000657 NM_009741 NM_177410 RefSeq (protein) NP_000624 NP_000648 NP_033871 NP_803129 Location (UCSC) Chr 18: 63.12 – 63.32 Mb Chr 1: 106.47 – 106.64 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Bcl-2, encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 ...
Protein toxicity is the effect of the buildup of protein metabolic waste compounds, like urea, uric acid, ammonia, and creatinine. Protein toxicity has many causes, including urea cycle disorders, genetic mutations, excessive protein intake, and insufficient kidney function, such as chronic kidney disease and acute kidney injury .
Loving a protein so much that you eat it daily isn’t necessarily bad. But if chicken breast is the bee’s knees for you, consider having them once and varying the rest of your menu.
Protein is a nutrient that's essential for muscle growth and maintenance, metabolism regulation, and a healthy immune system. ... Saturated fat is problematic because it can raise LDL (bad ...
Protein supplements are a quick and easy way to reach your daily protein needs, especially if you're looking to build muscle or if protein is lacking in your diet. Here are some of the ingredients ...
BAD is a pro-apoptotic protein of the Bcl-2 family. Akt1 can phosphorylate BAD on Ser136, [21] which makes BAD dissociate from the Bcl-2/Bcl-X complex and lose the pro-apoptotic function. [22] Akt1 can also activate NF-κB via regulating IκB kinase (IKK), thus result in transcription of pro-survival genes. [23]
The BH3 interacting-domain death agonist, or BID, gene is a pro-apoptotic member of the Bcl-2 protein family. [5] Bcl-2 family members share one or more of the four characteristic domains of homology entitled the Bcl-2 homology (BH) domains (named BH1, BH2, BH3 and BH4), and can form hetero- or homodimers.