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Shingles is caused by varicella zoster virus (VZV), an alpha-herpesvirus. Initial VZV infection usually occurs in childhood causing chickenpox. After this resolves, the virus is not eliminated from the body, but remains latent in the nerve cell bodies of the dorsal root or trigeminal ganglia, without causing symptoms.
Once the chickenpox has resolved, the virus can remain dormant (inactive) in human nerve cells (dorsal root ganglia or cranial nerves) [11] for years or decades, after which it may reactivate and travel along nerve bodies to nerve endings in the skin, producing blisters.
Similar to the herpes simplex viruses, after primary infection with VZV (chickenpox), the virus lies dormant in neurons, including the cranial nerve ganglia, dorsal root ganglia, and autonomic ganglia. Many years after the person has recovered from initial chickenpox infection, VZV can reactivate to cause shingles. [4]
The shingles vaccine is a two-dose series and provides protection for at least seven years, Tonizzo said. “It’s safe in everyone and is 90% to 95% effective.
Doctors “can provide personalized information and reassurance and develop the best action plan for your health,” he says. If you’re over 50, doctors say there are a few vaccines that you ...
The study, which was published in Nature Medicine on July 25, analyzed data from more than 200,000 people who received a shingles vaccine. Some received the live shingles vaccine, called Zostavax ...
A dorsal root ganglion (or spinal ganglion; also known as a posterior root ganglion [1]) is a cluster of neurons (a ganglion) in a dorsal root of a spinal nerve. The cell bodies of sensory neurons known as first-order neurons are located in the dorsal root ganglia. [2] The axons of dorsal root ganglion neurons are known as afferents.
The shingles vaccine is actually a two-shot series, but you only have to complete the series once. Then you should be good to go. Read on for my information on the shingles vaccine, and why it's ...