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Dapagliflozin, sold under the brand names Farxiga (US) and Forxiga (EU) among others, is a medication used to treat type 2 diabetes. [ 6 ] [ 7 ] [ 10 ] It is also used to treat adults with heart failure and chronic kidney disease .
Pleiotropic effects of this class have been attributed to a variety of its pharmacodynamic actions such as natriuresis, hemoconcentration, deactivation of renin-angiotensin-aldosterone system, ketone body formation, alterations in energy homeostasis, glycosuria, lipolysis, anti‐inflammatory, and antioxidative actions. [60] [3]
Common side effects include hyperventilation, anorexia, abdominal pain, nausea, vomiting, lethargy, mental status changes, hypotension, acute kidney injury, and vaginal yeast infections. [2] Rarer but more serious side effects include a skin infection of the groin called Fournier's gangrene and a form of diabetic ketoacidosis with normal blood ...
Patients who receive the drug are also counseled on this potential side effect. Users of the popular weight loss drugs have already reported a number of side effects — from personality changes ...
People were more likely to have quit if they had developed gastrointestinal side effects, the study found—but insurance hassles and expenses may also be factors, since the drugs can cost more ...
Even more savings will come with the three diabetes medications listed: Jardiance, Januvia, and Farxiga. According to the White House, 3.7 million Medicare enrollees used these drugs in 2023.
How we refer to weight-loss side effects matters. Doctors agree problems mainly arise due to prescribers being irresponsible rather than the drugs themselves. Dr.
Thiazolidinedione ligand dependent transactivation is responsible for the majority of anti-diabetic effects. The activated PPAR/RXR heterodimer binds to peroxisome proliferator hormone response elements upstream of target genes in complex with a number of coactivators such as nuclear receptor coactivator 1 and CREB binding protein, this causes upregulation of genes (for a full list see PPARγ):
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