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  2. Ka/Ks ratio - Wikipedia

    en.wikipedia.org/wiki/Ka/Ks_ratio

    A 2022 study reported that synonymous mutations in representative yeast genes are mostly strongly non-neutral, which calls into question the assumptions underlying use of the K a /K s ratio. [ 4 ] In addition, as time progresses, it is possible for a site to undergo multiple modifications.

  3. Gene conversion - Wikipedia

    en.wikipedia.org/wiki/Gene_conversion

    Gene conversion is the process by which one DNA sequence replaces a homologous sequence such that the sequences become identical after the conversion. [1] Gene conversion can be either allelic , meaning that one allele of the same gene replaces another allele, or ectopic , meaning that one paralogous DNA sequence converts another.

  4. MODY 2 - Wikipedia

    en.wikipedia.org/wiki/MODY_2

    These loss-of-function mutations result in a glucokinase molecule that is less sensitive or less responsive to rising levels of glucose. The beta cells in MODY 2 have a normal ability to make and secrete insulin, but do so only above an abnormally high threshold (e.g., 126–144 mg/dl, or 7-8 mM).

  5. Transversion - Wikipedia

    en.wikipedia.org/wiki/Transversion

    The location of a transversion mutation on a gene coding for a protein correlates with the extent of the mutation. If the mutation occurs at a site that is not involved with the shape of a protein or the structure of an enzyme or its active site, the mutation will not have a significant effect on the cell or the enzymatic activity of its proteins.

  6. Allele frequency - Wikipedia

    en.wikipedia.org/wiki/Allele_frequency

    In natural populations natural selection (adaptation mechanism), gene flow, and mutation combine to change allele frequencies across generations. Genetic drift causes changes in allele frequency from random sampling due to offspring number variance in a finite population size, with small populations experiencing larger per generation ...

  7. Genetic distance - Wikipedia

    en.wikipedia.org/wiki/Genetic_distance

    Figure 1: Genetic distance map by Cavalli-Sforza et al. (1994) [1] Genetic distance is a measure of the genetic divergence between species or between populations within a species, whether the distance measures time from common ancestor or degree of differentiation. [2]

  8. The Huckberry waxed canvas jacket never goes on sale: But it ...

    www.aol.com/lifestyle/the-huckberry-waxed-canvas...

    This hearty jacket is made in the USA, durable enough to handle farm work and warm enough to keep you safe in the winter. It's 15% through November 15 and won't go back on sale until sometime in 2025.

  9. Single-nucleotide polymorphism - Wikipedia

    en.wikipedia.org/wiki/Single-nucleotide_polymorphism

    The upper DNA molecule differs from the lower DNA molecule at a single base-pair location (a G/A polymorphism) In genetics and bioinformatics, a single-nucleotide polymorphism (SNP / s n ɪ p /; plural SNPs / s n ɪ p s /) is a germline substitution of a single nucleotide at a specific position in the genome.