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Remove or add restriction sites or other sequence motifs; Recode open reading frames; Check translation frames and fusion junctions; Design oligonucleotides to sequence primers, includes a real time melting point calculator; Cloning tool with drag and drop ability to cut, combine, and clone insert and vector; Gene Designer clones with a drag ...
Simulation of protein sequences along phylogenies under empirical and structurally constrained substitution models of protein evolution Simulating sequences forward in time, substitution models M. Arenas, H.G. Dos Santos, D. Posada, U. Bastolla ProteinEvolverABC [35] Coestimation of recombination and substitution rates in protein sequences
The fourth is a great example of how interactive graphical tools enable a worker involved in sequence analysis to conveniently execute a variety if different computational tools to explore an alignment's phylogenetic implications; or, to predict the structure and functional properties of a specific sequence, e.g., comparative modelling.
MegAlign Pro (Lasergene Molecular Biology) Software to align DNA, RNA, protein, or DNA + protein sequences via pairwise and multiple sequence alignment algorithms including MUSCLE, Mauve, MAFFT, Clustal Omega, Jotun Hein, Wilbur-Lipman, Martinez Needleman-Wunsch, Lipman-Pearson and Dotplot analysis. Both: Both: DNASTAR: 1993-2016 MUMmer suffix ...
Sequence analysis in molecular biology includes a very wide range of processes: The comparison of sequences to find similarity, often to infer if they are related ( homologous ) Identification of intrinsic features of the sequence such as active sites , post translational modification sites, gene-structures , reading frames , distributions of ...
Remove low-complexity region or sequence repeats in the query sequence. "Low-complexity region" means a region of a sequence composed of few kinds of elements. These regions might give high scores that confuse the program to find the actual significant sequences in the database, so they should be filtered out.
Sequence alignment is a fundamental research method for modern biology. The most common sequence alignment for protein is to look for similarity between different sequences in order to infer function or establish evolutionary relationships.
Multiple sequence alignment (MSA) is the process or the result of sequence alignment of three or more biological sequences, generally protein, DNA, or RNA. These alignments are used to infer evolutionary relationships via phylogenetic analysis and can highlight homologous features between sequences.