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  2. Primidone - Wikipedia

    en.wikipedia.org/wiki/Primidone

    Primidone and the other enzyme-inducing anticonvulsants can cut the half-life of antipyrine roughly in half (6.2 ± 1.9 h vs. 11.2 ± 4.2 h), and increases the clearance rate by almost 70%. Phenobarbital reduces the half-life to 4.8 ± 1.3 and increases the clearance by almost 109%. [66]

  3. Phenobarbital - Wikipedia

    en.wikipedia.org/wiki/Phenobarbital

    Phenobarbital, also known as phenobarbitone or phenobarb, sold under the brand name Luminal among others, is a medication of the barbiturate type. [6] It is recommended by the World Health Organization (WHO) for the treatment of certain types of epilepsy in developing countries . [ 8 ]

  4. Anticonvulsant - Wikipedia

    en.wikipedia.org/wiki/Anticonvulsant

    Valproic acid, and its derivatives such as sodium valproate and divalproex sodium, causes cognitive deficit in the child, with an increased dose causing decreased intelligence quotient and use is associated with adverse neurodevelopmental outcomes (cognitive and behavioral) in children.

  5. Pharmacokinetics - Wikipedia

    en.wikipedia.org/wiki/Pharmacokinetics

    Population pharmacokinetics seeks to identify the measurable pathophysiologic factors and explain sources of variability that cause changes in the dose-concentration relationship and the extent of these changes so that, if such changes are associated with clinically relevant and significant shifts in exposures that impact the therapeutic index ...

  6. Clonazepam - Wikipedia

    en.wikipedia.org/wiki/Clonazepam

    Clonazepam increases the levels of primidone [104] and phenobarbital. [ 107 ] Combined use of clonazepam with certain antidepressants , anticonvulsants (such as phenobarbital , phenytoin , and carbamazepine ), sedative antihistamines , opiates , and antipsychotics , nonbenzodiazepines (such as zolpidem ), and alcohol may result in enhanced ...

  7. List of psychotropic medications - Wikipedia

    en.wikipedia.org/wiki/List_of_psychotropic...

    Depakote (valproic acid/sodium valproate) – an antiepileptic and mood stabilizer used to treat bipolar disorder, neuropathic pain and others; sometimes called an antimanic medication.

  8. Tedral - Wikipedia

    en.wikipedia.org/wiki/Tedral

    Tedral is also composed of phenobarbital, therefore, it is contraindicated for individuals with: [8] [5] [20] Hypersensitivity to phenobarbital, barbiturates or any component of the formulation. A history/manifest or latent porphyria; Liver impairment; Nephritic syndrome (at high dose) A history of sedative-hypnotic drug addiction

  9. Methylphenobarbital - Wikipedia

    en.wikipedia.org/wiki/Methylphenobarbital

    Methylphenobarbital (), also known as mephobarbital (USAN, JAN) and mephobarbitone (), marketed under brand names such as Mebaral, Mephyltaletten, Phemiton, and Prominal, is a drug which is a barbiturate derivative and is used primarily as an anticonvulsant, [2] but also as a sedative and anxiolytic.

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