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Calcium channel blockers, also known as calcium channel antagonists, are widely used for a number of health conditions. [8] Thus they are commonly present in many people's homes. In young children one pill may cause serious health problems and potentially death. [8]
The most common cause for hypocalcemia is iatrogenic hypoparathyroidism. [2] Other causes include other forms of hypoparathyroidism, vitamin D deficiency, kidney failure, pancreatitis, calcium channel blocker overdose, rhabdomyolysis, tumor lysis syndrome, and medications such as bisphosphonates or denosumab. [1]
Calcium channel blockers (CCB), calcium channel antagonists or calcium antagonists [2] are a group of medications that disrupt the movement of calcium (Ca 2+) through calcium channels. [3] Calcium channel blockers are used as antihypertensive drugs, i.e., as medications to decrease blood pressure in patients with hypertension.
Disorders of calcium metabolism occur when the body has too little or too much calcium. The serum level of calcium is closely regulated within a fairly limited range in the human body. In a healthy physiology, extracellular calcium levels are maintained within a tight range through the actions of parathyroid hormone , vitamin D and the calcium ...
As of 2014, no treatment strategy has yet been investigated in a randomized clinical trial. [1] Verapamil, nimodipine, and other calcium channel blockers may help reduce the intensity and frequency of the headaches. [1] A clinician may recommend rest and the avoidance of activities or vasoactive drugs which trigger symptoms (see § Causes). [1]
Studies have shown that the intrathecal injection of the calcium channel inhibitor ziconotide, to block the N-type calcium channels, have produced alleviation of intractable pain. [12] Blockade of the N-type calcium channel is a potential therapeutic strategy for the treatment of alcoholism. Because prolonged alcohol exposure over time has been ...
Healthy term infants go through a physiological nadir of serum calcium levels at 7.5 - 8.5 mg/dL by day 2 of life. Hypocalcemia is a low blood calcium level. A total serum calcium of less than 8 mg/dL (2mmol/L) or ionized calcium less than 1.2 mmol/L in term neonates is defined as hypocalcemia. In preterm infants, it is defined as less than 7mg ...
[68] β-blockers improve left ventricular filling and relaxation and thereby lessen symptoms. In some children, β–blockers (e.g., propranolol) were shown effective to reduce the risk of sudden death. [68] Further, calcium channel blockers (verapamil) and antiarrhythmic drugs may be used as an adjunct therapy to β-blockers in symptomatic ...