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[15] [12] [13] The elimination half-life of mCPP is 2.6 to 16.0 hours and is longer than that of trazodone. [ 11 ] [ 12 ] [ 14 ] Metabolites are conjugated to gluconic acid or glutathione and around 70 to 75% of 14 C-labelled trazodone was found to be excreted in the urine within 72 hours. [ 138 ]
Absorption half-life 1 h, elimination half-life 12 h. Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (C max) to half of C max in the blood plasma.
The elimination half-life is how long it takes for half of the drug to be eliminated by the body. "Time to peak" refers to when maximum levels of the drug in the blood occur after a given dose. "Time to peak" refers to when maximum levels of the drug in the blood occur after a given dose.
Elimination half-life: 8–20 hours: Duration of action ... atypical antidepressants (trazodone, ... the effectiveness of temazepam and speed up its elimination half ...
The medication has an elimination half-life of about 8 hours [1] or of 6 to 10 hours. [5] [7] The half-life of daridorexant may be longer in elderly individuals compared to young adults (9–10 hours in the elderly versus 6 hours in young adults). [7]
[2] [51] [52] The elimination half-life of mCPP is 4 to 14 hours. [2] mCPP is a metabolite of a variety of other piperazine drugs including trazodone, nefazodone, etoperidone, enpiprazole, mepiprazole, cloperidone, peraclopone, and BRL-15,572. [52] [additional citation(s) needed] It is formed by dealkylation via CYP3A4. [52]
Biological half-life is given as 18 hours or 20 to 40 hours in different sources. 80% or 67% of a radiolabelled dose was recovered from the feces, and 9% or 19% from the urine. [ 3 ] [ 9 ] History
Nefazodone has a short elimination half-life of about 2 to 4 hours. [2] Its metabolite hydroxynefazodone similarly has an elimination half-life of about 1.5 to 4 hours, whereas the elimination half-lives of triazoledione and mCPP are longer at around 18 hours and 4 to 8 hours, respectively. [2]