Search results
Results from the WOW.Com Content Network
[15] [12] [13] The elimination half-life of mCPP is 2.6 to 16.0 hours and is longer than that of trazodone. [ 11 ] [ 12 ] [ 14 ] Metabolites are conjugated to gluconic acid or glutathione and around 70 to 75% of 14 C-labelled trazodone was found to be excreted in the urine within 72 hours. [ 138 ]
Absorption half-life 1 h, elimination half-life 12 h. Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (C max) to half of C max in the blood plasma.
The elimination half-life is how long it takes for half of the drug to be eliminated by the body. "Time to peak" refers to when maximum levels of the drug in the blood occur after a given dose. "Time to peak" refers to when maximum levels of the drug in the blood occur after a given dose.
Alternatively, since the radioactive decay contributes to the "physical (i.e. radioactive)" half-life, while the metabolic elimination processes determines the "biological" half-life of the radionuclide, the two act as parallel paths for elimination of the radioactivity, the effective half-life could also be represented by the formula: [1] [2]
Chemical structure of the serotonin antagonist and reuptake inhibitor trazodone.. Serotonin antagonist and reuptake inhibitors (SARIs) are a class of drugs used mainly as antidepressants, but also as anxiolytics and hypnotics.
[2] [51] [52] The elimination half-life of mCPP is 4 to 14 hours. [2] mCPP is a metabolite of a variety of other piperazine drugs including trazodone, nefazodone, etoperidone, enpiprazole, mepiprazole, cloperidone, peraclopone, and BRL-15,572. [52] [additional citation(s) needed] It is formed by dealkylation via CYP3A4. [52]
The medication has an elimination half-life of about 8 hours [1] or of 6 to 10 hours. [5] [7] The half-life of daridorexant may be longer in elderly individuals compared to young adults (9–10 hours in the elderly versus 6 hours in young adults). [7] Its half-life is shorter than that of other orexin receptor antagonists such as suvorexant (12 ...
Like diazepam, it has a long elimination half-life and long-acting active metabolites. [25] [69] Management of benzodiazepine dependence involves considering the person's age, comorbidity and the pharmacological pathways of benzodiazepines. [70]