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The most common reason parents reported as the cause of lost ASD diagnosis was new information about the child (73.5%), such as a replacement diagnosis. Other reasons included a diagnosis given so the child could receive ASD treatment (24.2%), ASD treatment success or maturation (21%), and parents disagreeing with the initial diagnosis (1.9%).
Research-determined cut-offs identify the potential diagnosis of autism spectrum disorder, allowing a standardized assessment of autistic symptoms. The Autism Diagnostic Interview-Revised (ADI-R), a companion instrument, is a structured interview conducted with the parents of the referred individual to cover the subject's full developmental ...
Rett syndrome brain samples and autism brain samples show immaturity of dendrite spines and reduction of cell-body size due to errors in coupled regulation between MECP2 and EGR2. [62] However, because of the multigene involvement in autism, the MECP2 gene has only been identified as a vulnerability factor in autism. [63]
The DSM-5 has the diagnosis of Specific Learning Disorder, which is a disorder where one has difficulties in being able to learn and use academic skills. Specific learning disorder has specifiers for the areas that one faces difficulties in, with those specifiers being impairment in reading, impairment in writing, and impairment in mathematics. [2]
The age of diagnosis can range from 9 months to 14 years, and the mean age is 4 years old in the USA. [11] On average each case of ASD is tested at three different diagnostic centers before confirmed. Early diagnosis of the disorder can diminish familial stress, speed up referral to special educational programs and influence family planning. [12]
The diagnosis manual DSM-IV did not allow the co-diagnosis of ASD and attention deficit hyperactivity disorder (ADHD). However, following years of clinical research, the DSM-5 released in 2013 removed this prohibition of co-morbidity. Thus, individuals with autism spectrum disorder may also have a diagnosis of ADHD, with the modifiers of a ...
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Conversely, noting the failure to find specific alleles that reliably cause autism or rare mutations that account for more than 5% of the heritable variation in autism established by twin and adoption studies, research in evolutionary psychiatry has concluded that it is unlikely that there is or has been selection pressure for autism when ...