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P24 is a structural protein that plays a crucial role in the formation and stability of the viral capsid, which protects the viral RNA. p24 capsid protein's roles in the HIV replicative process are summarized as follows: [citation needed] Fusion: HIV replication cycle begins when HIV fuses with the surface of the host cell.
A reverse transcriptase (RT) is an enzyme used to convert RNA genome to DNA, a process termed reverse transcription.Reverse transcriptases are used by viruses such as HIV and hepatitis B to replicate their genomes, by retrotransposon mobile genetic elements to proliferate within the host genome, and by eukaryotic cells to extend the telomeres at the ends of their linear chromosomes.
The HIV-1 integrase (IN) is a key enzyme in the replication mechanism of retroviruses. [9] It is responsible for the transfer of virally encoded DNA into the host chromosome which is a necessary event in retroviral replication. [10]
This file was derived from: Hiv replication cycle.gif This image has been created during "DensityDesign Integrated Course Final Synthesis Studio" at Polytechnic University of Milan, organized by DensityDesign Research Lab in 2016. Image is released under CC-BY-SA licence. Attribution goes to "Chiara Cirella, DensityDesign Research Lab".
Reverse-transcriptase inhibitors (RTIs) are a class of antiretroviral drugs used to treat HIV infection or AIDS, and in some cases hepatitis B. RTIs inhibit activity of reverse transcriptase, a viral DNA polymerase that is required for replication of HIV and other retroviruses.
Two types of HIV have been characterized: HIV-1 and HIV-2. HIV-1 is the virus that was initially discovered and termed both lymphadenopathy associated virus (LAV) and human T-lymphotropic virus 3 (HTLV-III). HIV-1 is more virulent and more infective than HIV-2, [20] and is the cause of the majority of HIV infections globally. The lower ...
HIV-1 Protease has the classic AspThrGly of Aspartyl Proteases. These amino acids are located at position 25, 26, and 27, and are responsible for the catalytic activity. With its integral role in HIV replication, HIV protease has been a prime target for drug therapy.
HIV/AIDS explained in a simple way HIV replication cycle. After the virus enters the body, there is a period of rapid viral replication, leading to an abundance of virus in the peripheral blood. During primary infection, the level of HIV may reach several million virus particles per milliliter of blood. [101]