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The aortic valve normally has three cusps or leaflets, although in 1–2% of the population it is found to congenitally have two leaflets. [1] The aortic valve is the last structure in the heart the blood travels through before stopping the flow through the systemic circulation. [1]
Similarly, patient that have a bicuspid valve, with two leaflets, as opposed to a tricuspid with three, are more at risk of fibrosis and calcification since the mechanical stress that’s usually distributed between three leaflets is now being split by two leaflets, and therefore they see more stress per leaflet.
[44] [45] Aortic valve calcium scoring by multidetector computed tomography (CT-AVC) is used to quantify the degree of calcification of the aortic valve. [46] According to the 2021 ESC/EACTS Guidelines for the management of valvular heart disease the recommended thresholds indicating severe aortic stenosis are > 1200 AU in women and > 2000 AU ...
More than 50% of patients with aortic valve stenosis have a congenital heart abnormality called a bicuspid aortic valve. The aortic valve is normally three leaflets but when it is bicuspid it is made of two. [6] This increases the risk for aortic stenosis due to increased stress on the leaflets, calcium deposition, turbulent blood flow, and ...
Calcification of the leaflets of the aortic valve is a common with increasing age, but the mechanism is likely to be more related to increased lipoprotein deposits and inflammation than the "wear and tear" of advance age. [17] Aortic stenosis due to calcification of tricuspid aortic valve with age [16] comprises >50% of the
Bicuspid aortic valve – Formation of two valve leaflets in the aortic valve instead of three leaflets. This leads to aortic stenosis as the valve prematurely calcifies (as compared to calcification of a trileaflet valve). Coarctation of the aorta (CoA) – Narrowing of the aorta, typically of the aortic arch and is classically found in Turner ...
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