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Transcription factor Sp7, also called Osterix (Osx), is a protein that in humans is encoded by the SP7 gene. [5] It is a member of the Sp family of zinc-finger transcription factors [5] It is highly conserved among bone-forming vertebrate species [6] [7] It plays a major role, along with Runx2 and Dlx5 in driving the differentiation of mesenchymal precursor cells into osteoblasts and ...
Runx2 is responsible for inducing the differentiation of multipotent mesenchymal cells into immature osteoblasts, as well as activating expression of several key downstream proteins that maintain osteoblast differentiation and bone matrix genes. Knock-out of the DNA-binding activity results in inhibition of osteoblastic differentiation. Because ...
OPN expression in bone predominantly occurs by osteoblasts and osteocyctes (bone-forming cells) as well as osteoclasts (bone-resorbing cells). [29] Runx2 (aka Cbfa1) and osterix (Osx) transcription factors are required for the expression of OPN [ 30 ] Runx2 and Osx bind promoters of osteoblast-specific genes such as Col1α1 , Bsp , and Opn and ...
In osteolytic bone metastases, tumour cells migrate to the bone and release cytokines such as parathyroid hormone-related protein (PTHrP), IL-8 and PGE2. [44] These cytokines act on osteoblasts to increase RANKL and decrease OPG expression resulting in excess bone resorption. [44]
The level of RANKL expression does not linearly correlate to the effect of this ligand. High protein expression of RANKL is commonly detected in the lungs, thymus and lymph nodes. Low protein expression is found in bone marrow, the stomach, peripheral blood, the spleen, the placenta, leukocytes, the heart, the thyroid, and skeletal muscle. [9]
Bone morphogenetic protein 6 is a protein that in humans is encoded by the BMP6 gene. [4] [5] [6] The protein encoded by this gene is a member of the TGFβ superfamily. Bone morphogenetic proteins are known for their ability to induce the growth of bone and cartilage. BMP6 is able to induce all osteogenic markers in mesenchymal stem cells.
16973 Ensembl ENSG00000162337 ENSMUSG00000024913 UniProt O75197 Q91VN0 RefSeq (mRNA) NM_001291902 NM_002335 NM_008513 RefSeq (protein) NP_001278831 NP_002326 NP_032539 Location (UCSC) Chr 11: 68.31 – 68.45 Mb Chr 19: 3.63 – 3.74 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Low-density lipoprotein receptor-related protein 5 is a protein that in humans is encoded by the LRP5 ...
Sclerostin is a protein that in humans is encoded by the SOST gene. [5] It is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists.