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The ErbB protein family consists of 4 members ErbB-1, also named epidermal growth factor receptor (EGFR) ErbB-2, also named HER2 in humans and neu in rodents; ErbB-3, also named HER3; ErbB-4, also named HER4; v-ErbBs are homologous to EGFR, but lack sequences within the ligand binding ectodomain.
Receptor tyrosine-protein kinase erbB-4 is a receptor tyrosine kinase that is a member of the epidermal growth factor receptor family.ERBB4 is a single-pass type I transmembrane protein with multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif.
HER2 is colocalised and most of the time, coamplified with the gene GRB7, which is a proto-oncogene associated with breast, testicular germ cell, gastric, and esophageal tumours. HER2 proteins have been shown to form clusters in cell membranes that may play a role in tumorigenesis.
The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). In many cancer types, mutations affecting EGFR expression or activity could result in cancer. [6]
83961 Ensembl ENSG00000169752 ENSMUSG00000032311 UniProt Q8WWG1 Q9WTX4 RefSeq (mRNA) NM_138573 NM_032002 RefSeq (protein) NP_612640 NP_114391 Location (UCSC) Chr 15: 75.94 – 76.06 Mb Chr 9: 55.13 – 55.23 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene. Function ...
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A Northern California community came together Friday night to pray for two little boys who underwent surgery and remain in critical condition after they were wounded in a shooting at a small ...
In the late 70s Graf co-discovered several cell-derived oncogenes acquired by avian retroviruses, designated Mac (later changed into Myc), Erb and Myb. [4] He found that several naturally occurring virus strains have acquired various pairwise combinations of oncogenes and that these cooperate to cause acute leukemia, [5] an early example for the multigenic origin of cancers.