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These guidelines recommend statin therapy for adults between forty and seventy-five who have diabetes, high cholesterol levels, or an estimated 10-year atherosclerotic cardiovascular disease risk ...
“These findings will potentially reduce the hesitancy of many physicians to start statin therapy in patients over 75 and may even lead to a change ... some doctors discontinue statins in older ...
“When recommended statin therapy, women were more likely to decline it and more likely to discontinue it after starting treatment. Women have less belief in the safety and effectiveness of ...
On average, statins can lower LDL cholesterol by 1.8 mmol/L (70 mg/dL), which translates into an estimated 60% decrease in the number of cardiac events (heart attack, sudden cardiac death) and a 17% reduced risk of stroke after long-term treatment. [36] A greater benefit is observed with high-intensity statin therapy. [37]
Recent research (Nixon & Vendelø, 2016) shows that General Practitioners (GPs) who actively consider discontinuation, are reluctant to do so, as they experience that the safest decision is to continue prescriptions, rather than discontinue them. In part this is due to the ambiguity about the appropriateness of discontinuing medication.
The pharmacological results from cerivastatin show that it is the most active HMG-CoA-reductase inhibitor among reported statins. Due to its high enzyme affinity, it would seem to offer ultra-low dose therapy in the microgram range. However, due to its relatively severe adverse effects in comparison to other statins, its market use was ...
Statins are one of the most commonly prescribed drugs in the UK, with millions taking them to cut their chance of a heart attack or stroke. Stopping statin treatment early ‘could reduce ...
More than one third of women believe that doctors are too aggressive when it comes to statin medication, versus 28% of men, and 20% would discontinue statin treatment without consulting their ...