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A 2011 study based on the trial found that the risk of prostate cancer was elevated by 17% in the group that took vitamin E supplements, which was statistically significant. [8] [13] A 2014 study based on SELECT data found that selenium supplementation increased the risk of high-grade prostate cancer in men who had a higher baseline selenium ...
Methaneseleninic acid shows potential anticancer activity and is a model for studying the anticancer effects of selenium in vitro. [7] Methaneseleninic acid shows superior in vivo inhibitory efficacy toward human prostate cancer compared to selenomethionine or selenite (ion). [8]
Methylselenocysteine, also known as Se-methylselenocysteine, is an analog of S-methylcysteine in which the sulfur atom is replaced with a selenium atom. It is an inhibitor of DMBA-induced mammary tumors [1] and a "chemopreventive agent that blocks cell cycle progression and proliferation of premalignant mammary lesions and induces apoptosis of cancer cell lines in culture."
Selenium is toxic in high concentrations. As sodium selenite, the chronic toxic dose for human beings was described as about 2.4 to 3 milligrams of selenium per day. [7] In 2000, the US Institute of Medicine set the adult Tolerable upper intake levels (UL) for selenium from all sources - food, drinking water and dietary supplements - at 400 μg/day. [8]
One review of studies found the reported benefits of phytoestrogens include a lower risk of menopausal symptoms, cardiovascular disease and cancer of the breast, prostate, bowel cancer and uterus.
Selenium is found in metal sulfide ores, where it substitutes for sulfur. Commercially, selenium is produced as a byproduct in the refining of these ores. Minerals that are pure selenide or selenate compounds are rare. The chief commercial uses for selenium today are glassmaking and pigments. Selenium is a semiconductor and is used in photocells.
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