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Keratoconus (KC) is a disorder of the eye that results in progressive thinning of the cornea. [3] This may result in blurry vision, double vision, nearsightedness, irregular astigmatism, [4] and light sensitivity leading to poor quality-of-life. [3] [5] Usually both eyes are affected. [3]
Keratoconus, a progressive, noninflammatory, bilateral, asymmetric disease, characterized by paraxial stromal thinning and weakening that leads to corneal surface distortion. [ 2 ] Keratoglobus , a rare noninflammatory corneal thinning disorder, characterised by generalised thinning and globular protrusion of the cornea.
Keratoconus in itself is a pattern of the entire cornea, therefore every measurement just focusing on one layer, might not be enough for a state of the art diagnosis. Especially early cases of keratoconus might be missed by a plain topographic measurement, which is critical if refractive surgery is being considered. [ 7 ]
KC6 ("Keratoconus gene 6") is a novel gene located on chromosome 18 at p12.3. It was discovered by Rabinowitz et al. (2005) [1] in a study whose aims were finding genes expressed in human cornea and increasing the knowledge of molecular changes in keratoconus. It lies adjacent to the PIK3C3 gene, but is apparently non-protein coding. Its ...
Corneal pachymetry is the process of measuring the thickness of the cornea.A pachymeter is a medical device used to measure the thickness of the eye's cornea.It is used to perform corneal pachymetry prior to refractive surgery, for Keratoconus screening, LRI surgery [1] and is useful in screening for patients suspected of developing glaucoma among other uses.
Corneal transplantation, also known as corneal grafting, is a surgical procedure where a damaged or diseased cornea is replaced by donated corneal tissue (the graft). When the entire cornea is replaced it is known as penetrating keratoplasty and when only part of the cornea is replaced it is known as lamellar keratoplasty.
Clinical studies support vector planning both in healthy astigmatic eyes [17] [18] [19] and in eyes with keratoconus. [ 20 ] Additionally, Alpins and Stamatelatos showed that combining refraction (using wavefront measurements) with Vector Planning provided better visual outcomes than using wavefront planning alone.
An eye doctor examining a patient with a keratometer Typical presentations of keratoconus as detected through a keratometer Shin Nippon Nvision K-5001 Refkeratometer The optics inside a Shin Nippon Nvision K-5001 Refkeratometer