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Many oral forms of medications can be crushed and suspended in water to be given via a rectal catheter. The rectal route of administration is useful for patients with any digestive tract motility problem, such as dysphagia , ileus , or bowel obstruction , that would interfere with the progression of the medication through the tract.
Midodrine, also known as 3,6-dimethoxy-β-hydroxy-N-aminoethanonyl-2-phenylethylamine, is a substituted phenethylamine derivative. [4] Midodrine is an odorless, white, crystalline powder, soluble in water and sparingly soluble in methanol. [19] Midodrine's experimental log P is -0.5 and its predicted log P ranges from -0.49 to -0.95.
Medications delivered to the distal one-third of the rectum at least partially avoid the "first pass effect" through the liver, which allows for greater bio-availability of many medications than that of the oral route. Rectal mucosa is highly vascularized tissue that allows for rapid and effective absorption of medications. [15]
Desglymidodrine, also known as 3,6-dimethoxy-β-hydroxy-2-phenylethylamine, is a substituted phenethylamine derivative. [ 4 ] [ 5 ] Midodrine's experimental log P is -0.5 and its predicted log P ranges from -0.49 to -0.95.
[1] [2] [29] However, one study of 13 patients with hepatorenal syndrome showed significant improvement in kidney function when the two were used together (with midodrine given orally, octreotide given subcutaneously and both dosed according to blood pressure), with three patients surviving to discharge. [30]
A nutrient enema, also known as feeding per rectum, rectal alimentation, or rectal feeding, is an enema administered to provide nutrition in cases where normal eating is not possible. In modern medicine, nutrient enemas have been superseded by tube feeding and parenteral nutrition (intravenous feeding).
For women undergoing a medication abortion during the second trimester, having an IUD inserted early (five to 14 days after) vs. delayed (three to four weeks after) carries a slightly higher risk ...
Extended-release (or slow-release) formulations of morphine are those whose effect last substantially longer than bare morphine, availing for, e.g., one administration per day. Conversion between extended-release and immediate-release (or "regular") morphine is easier than conversion to or from an equianalgesic dose of another opioid with ...
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