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Sodium oxybate, sold under the brand name Xyrem among others, is a medication used to treat symptoms of narcolepsy: sudden muscle weakness and excessive daytime sleepiness. [ 3 ] [ 7 ] [ 8 ] It is used sometimes in France and Italy as an anesthetic given intravenously .
The authors of a 2010 Cochrane review [18] concluded that "GHB appears better than NTX and disulfiram in maintaining abstinence and preventing craving in the medium term (3 to 12 months)". It is sometimes used off-label for the treatment of fibromyalgia. [19] [20] GHB is the active ingredient of the prescription medication sodium oxybate (Xyrem).
Sodium oxybate (Xyrem) is an orphan drug which was designed specifically for the treatment of narcolepsy. Common side effects include nausea , dizziness , and hallucinations . [ 40 ] A 2016 study by Leu-Semenescu et al. found sodium oxybate reduced daytime sleepiness in IH to the same degree as in patients with narcolepsy type 1, and the drug ...
Avadel Pharmaceuticals Plc (NASDAQ: AVDL) has announced the presentation of secondary endpoint data from the Phase 3 REST-ON trial evaluating FT218 once-nightly formulation of sodium oxybate (ON ...
[2] [3] It contains a mixture of the oxybate salts calcium oxybate, magnesium oxybate, potassium oxybate, and sodium oxybate. [2] It is a central nervous system (CNS) depressant and it is taken by mouth. [2] Manufactured by the Jazz Pharmaceuticals company, it was approved for medical use in the United States in July 2020. [2] [4] [5]
Toby Fischer lives in South Dakota, where just 27 doctors are certified to prescribe buprenorphine -- a medication that blunts the symptoms of withdrawal from heroin and opioid painkillers. A Huffington Post analysis of government data found nearly half of all counties in America don't have such a certified physician. So every month, Fischer and his mother drive to Colorado to pick up their ...
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3-Hydroxybutanal – synthetic hypnotic and sedative drug; GHB (γ-hydroxybutyric acid) – neurotransmitter, drug of abuse; agonist of GHB receptor and GABA B receptor. Derivatives: sodium oxybate (sodium γ-hydroxybutanoate) – used to treat narcolepsy; same mechanism of action as GHB