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List of side effects of estradiol which may occur as a result of its use or have been associated with estrogen and/or progestogen therapy includes: [1] [2]. Gynecological: changes in vaginal bleeding, dysmenorrhea, increase in size of uterine leiomyomata, vaginitis including vaginal candidiasis, changes in cervical secretion and cervical ectropion, ovarian cancer, endometrial hyperplasia ...
Formulation methods include vaginal tablets, vaginal cream, vaginal gel, [4] vaginal suppository and vaginal ring. Medicines primarily delivered by intravaginal administration include vaginally administered estrogens and progestogens (a group of hormones including progesterone ), and antibacterials and antifungals to treat bacterial vaginosis ...
Vaginal rings (such as Oestring), which are polymeric drug delivery devices designed to provide controlled release of drugs to the vagina over extended periods of time. Although the Femring might be able to ease hot flashes, [3] this does not appear to be the case for other vaginal estrogen rings or vaginal creams. [8]
Side effects of estrogens like estrone include breast tenderness, breast enlargement, headache, nausea, fluid retention, and edema, among others. [5] Estrone is a naturally occurring and bioidentical estrogen, or an agonist of the estrogen receptor , the biological target of estrogens like endogenous estradiol . [ 5 ]
Side effects of estradiol acetate include breast tenderness, breast enlargement, nausea, headache, and fluid retention. [ 7 ] [ 5 ] [ 6 ] Estradiol acetate is an estrogen and hence is an agonist of the estrogen receptor , the biological target of estrogens like estradiol .
Estriol is well-tolerated and produces relatively few adverse effects. [12] [18] Side effects may include breast tenderness, vaginal discomfort and discharge, and endometrial hyperplasia. [12] [18] Estriol is a naturally occurring and bioidentical estrogen, or an agonist of the estrogen receptor, the biological target of estrogens like ...
Common side effects include irregular vaginal bleeding, nausea, sore breasts, vaginitis, mood changes, and headache. [4] Rare but serious side effects may include blood clots, toxic shock syndrome, anaphylaxis, gallstones, and liver problems. [4] Use is not recommended in those who both smoke and are over the age of 35. [4]
A vaginal tablet formulation containing 0.125 mg estradiol benzoate and 10 mg monalazone sodium (a vaginal disinfectant and spermicidal contraceptive) has been marketed under the brand name Malun 25. [43] Estradiol benzoate was also formerly available as 50 and 100 mg pellets for subcutaneous implantation and as a 2 mg/g ointment. [44
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