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Iron poisoning can occur when doses of 20 to 60 mg/kg or more of elemental iron is ingested with most cases reporting primarily gastrointestinal symptoms. [4] Systemic signs and symptoms shown in serious toxicity occur at higher doses exceeding 60 mg/kg. [ 5 ]
Since iron stores in the body are generally depleted, and there is a limit to what the body can process (about 2–6 mg/kg of body mass per day; i.e. for a 100 kg/220 lb man this is equal to a maximum dose of 200–600 mg/per day) without iron poisoning, this is a chronic therapy which may take 3–6 months.
220 mg (44 mg iron) per 5 mL* Ferrous Sulfate Elixir: 300 mg (60 mg iron) per 5 mL: Ferrous Sulfate Solution: 125 mg (25 mg iron) per mL* Fer-Gen-Sol® Drops: Teva Fer-In-Sol® Drops: Mead Johnson Tablets: 195 mg (39 mg iron)* Mol-Iron® Schering-Plough 300 mg (60 mg iron)* Feratab® Upsher-Smith 325 mg (65 mg iron)* Tablet, enteric-coated
Just 1½ cups of Cheerios provides 12.6 mg of iron, about 70% of the daily recommendation, while 1¼ cups of Kellogg’s Special K delivers 10.9 mg of iron, about 60% of the daily value.
The body can absorb up to 6 mg iron daily from the gastrointestinal tract. In many cases, the patient has a deficit of over 1,000 mg of iron which would require several months to replace. This can be given concurrently with erythropoietin to ensure sufficient iron for increased rates of erythropoiesis. [101]
For U.S. food and dietary supplement labeling purposes, the amount in a serving is expressed as a percent of Daily Value (%DV). For iron labeling purposes, 100% of the Daily Value was 18 mg, and as of May 27, 2016 remained unchanged at 18 mg. [173] [174] A table of the old and new adult daily values is provided at Reference Daily Intake.
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